X-ray Diffraction Methods for the Analysis of Metalloproteins

  • John R. Wright
  • Wayne A. Hendrickson
  • Shigemasa Osaki
  • Gordon T. James
Part of the Biochemistry of the Elements book series (BOTE, volume 5)


Research in the natural sciences is nearly always carried out in the context of a structural image of the subject material. This image or model, be it founded on experimental fact or imagined from analogous structures, provides a conceptual framework on which to base both theory and experiment. The relevant structural images in chemical research are those of the atomic arrangements in molecules. In the case of biochemistry it is our images of macromolecular structures (including their dynamic behavior) that relate directly to our approach to such basic problems as how enzymes work, how molecular aggregates self-assemble, how biological systems communicate information and transfer energy, how genes replicate, and how membranes transport specific ions. Metal atoms often play important roles in these biochemical processes, and structural images of such metal centers are pertinent to the study of these questions.


Metal Center Protein Crystal Acta Cryst Phase Determination Molecular Replacement 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John R. Wright
    • 1
  • Wayne A. Hendrickson
    • 2
  • Shigemasa Osaki
    • 3
  • Gordon T. James
    • 4
  1. 1.Southeastern Oklahoma State UniversityDurantUSA
  2. 2.Columbia UniversityNew YorkUSA
  3. 3.Hybritech, Inc.San DiegoUSA
  4. 4.Health Sciences CenterUniversity of ColoradoDenverUSA

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