The Central Pharmacology of Primary Afferents with Emphasis on the Disposition and Role of Primary Afferent Substance P

  • Tony L. Yaksh


Apart from the cranial nerves, all somatic and visceral information enters the nervous system by the primary Afferents, which largely have their first-order synapses in discrete regions of the dorsal gray matter of the spinal cord. Morphological (synaptic vesicles, end-plate thickening, synaptic cleft) and electrophysiological properties (presence of monosynaptic EPSPs but not monosynaptic IPSPs, synaptic delay) provide support for the premise that the afferent exerts its effect on the second-order neuron by the release of excitatory neurotransmitter(s).


Spinal Cord Dorsal Horn Vasoactive Intestinal Peptide Compound Action Potential Tail Flick 
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© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Tony L. Yaksh
    • 1
  1. 1.Departments of Neurosurgery and PharmacologyMayo ClinicRochesterUSA

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