Sensory-Discriminative Capacities of Nociceptive Pathways and Their Modulation by Behavior
Considerable progress has been made on the characterization of neural pathways participating in the sensory component of pain sensations. The sensory component of pain refers to the quality as well as the location, intensity, and temporal aspects of noxious or tissue-damaging stimuli. Recent advances include knowledge about the coding of pain signals and how these signals can be modified by control systems originating at other brain sites.
KeywordsDorsal Horn Spinal Dorsal Horn Nociceptive Neuron Noxious Heat Nociceptive Pathway
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- Bushnell, M. C., Jones, R. L., Duncan, G. H., and Dubner, R. Effects of attention on detection of noxious and innocuous thermal stimuli. Soc. Neurosci. Abstr. 9:473, 1983a.Google Scholar
- Dubner, R., and Hu, J. W. Myelinated (A-delta) nociceptive afferent innervating the monkey’s face. J. Dent. Res. 56:A167, 1977.Google Scholar
- Dubner, R., Beitel, R. E., and Brown, F. J. A behavioral animal model for the study of pain mechanisms in primates, in: Pain: New Perspectives in Therapy and Research, (M. Weisenberg and B. Tursky, eds.), Plenum Press, New York, 1976, pp. 155–170.Google Scholar
- Dubner, R., Price, D. D., Beitel, R. E., and Hu, J. W. Peripheral neural correlates of behavior in monkey and human related to sensory-discriminative aspects of pain, in: Pain in the Trigeminal Region (D.J. Anderson and B. Matthews, eds.), Elsevier, Amsterdam, 1977, pp. 57–66.Google Scholar
- Dubner, R., Bushnell, M. C., and Duncan, G. H. Behavioral and neural correlates of nociception, in: Current Topics in Pain Research and Therapy (T. Yokota and R. Dubner, eds.), Excerpta Medica, Amsterdam, 1983, pp. 45–55.Google Scholar
- Kosterlitz, H. W. Opioid peptides and pain—an update. Adv. Pain Res. Ther. 5:199–208, 1983.Google Scholar
- Maixner, W., Bushnell, M. C., Oliveras, J. L., Duncan, G. H., and Dubner, R. Thermal medullary dorsal horn neurons encode sensory intensity information in the noxious range. Pain [Suppl.] 2:5127, 1984.Google Scholar
- Melzack, R. The Puzzle of Pain, Basic Books, New York, 1973.Google Scholar
- Sherman, J. E., and Liebeskind, J. C. An endorphinergic, centrifugal substrate of pain modulation: recent findings, current concepts, and complexities, in: Pain (J.J. Bonica, ed.), Raven Press, New York, 1980, pp. 191–204.Google Scholar
- Willis, W. D. Control of nociceptive transmission in the spinal cord, in: Progress in Sensory Physiology (D. Ottoson, ed.), Springer-Verlag, Heidelberg, 1982, pp. 1–159.Google Scholar
- Willis, W. D., and Coggeshall, R. E. Sensory Mechanisms of the Spinal Cord. Plenum Press, New York, 1978.Google Scholar