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The Spinal Pathways Contributing to the Ascending Conduction and the Descending Modulation of Pain Sensations and Reactions

  • Charles J. VierckJr.
  • Joel D. Greenspan
  • Louis A. Ritz
  • David C. Yeomans

Abstract

Recent advances in pain research have strongly implicated a variety of transmitters within the dorsal horn of the spinal cord as modulators of conduction from peripheral nociceptors to ascending pathways (see Hammond, Chapter 15; Ruda, Chapter 7; Yaksh, Chapter 8; and several recent reviews including: Basbaum and Fields, 1984; La Motte and de Lanerolle, 1983; Light et ai, 1983; Schmauss and Yaksh, 1984; Westlund et al., 1984). These findings have supplemented and refined a wealth of anatomic and physiological information on synaptic interactions within the dorsal horn that are relevant to pain coding (see Willis, Chapter 11; Cervero, Chapter 9). The weakest link in this intense effort to understand the totality of influences on pain transmission within the spinal cord (Kerr, 1975b) has been the behavioral analysis of pain sensitivity in human patients and laboratory animals (primarily rats, cats, and monkeys).

Keywords

Dorsal Horn Pain Sensitivity Dorsal Column Spinothalamic Tract Electrocutaneous Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Charles J. VierckJr.
    • 1
  • Joel D. Greenspan
    • 2
  • Louis A. Ritz
    • 3
  • David C. Yeomans
    • 1
  1. 1.Department of Neuroscience and Center for Neurobiological SciencesUniversity of Florida College of MedicineGainesvilleUSA
  2. 2.Department of PhysiologyUniversity of North Carolina School of MedicineChapel HillUSA
  3. 3.Departments of Neurological Surgery and NeuroscienceUniversity of Florida College of MedicineGainesvilleUSA

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