Studies on Phase Transitions in the Dimorphic Pathogen Histoplasma capsulatum
Histoplasma capsulatum, the etiological agent of histoplasmosis, is a dimorphic pathogenic fungus. The disease histoplasmosis occurs in many different parts of the world, but has a particularly high prevalence in temperate and subtropical zones such as the Ohio and Mississippi river valleys of the United States, South and Central America, parts of the Mediterranean basin, and West Africa (P. Q. Edwards and Billings, 1971). The epidemiology of H. capsulatum and problems related to human infection have been extensively studied (Sweany, 1960; Ajello et al., 1971; Schwarz, 1981). The nature of dimorphism in H. capsulatum has also received a great deal of interest ever since the fungus was observed in tissue and cultured in vitro and discovered to have a saprophytic hyphal phase and a parasitic yeast phase (DeMonbreun, 1934).
KeywordsYeast Cell Alternate Oxidase Shunt Pathway Hyphal Cell Histoplasma Capsulatum
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