The existence of two morphological entities of Blastomyces dermatitidis, the causative agent of blastomycosis (North American blastomycosis, Gilchrist’s disease), was recognized by Gilchrist and Stokes (1898) soon after the disease was first described by Gilchrist (1896). Gilchrist and Stokes (1898) named the fungus and succeeded in culturing it at room temperature despite gross contamination of the cultures with pyogenic cocci. Ricketts (1901), however, was the first to publish detailed in vitro appearances of both yeast and mycelial forms, and it was he who suggested that temperature was a key factor in determining the type of growth observed. In an equally detailed and accurate presentation, Hamburger (1907) confirmed the importance of temperature in determining the morphological type and described how the “capsule” of the yeastlike cell ruptured, leaving “collarlike” projections through which a new bud was formed or a germ tube was initiated.
KeywordsYeast Cell Germ Tube Amino Sugar Yeast Form Mycelial Form
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