Abstract
Many fungi have a remarkable ability to alter normal vegetative developmental sequences in response to environmental change. This ability is common among the fungi responsible for the majority of different human mycoses. With the invasion of tissue and the establishment of infection, certain fungi that are pathogenic for humans differentiate into morphologically distinct growth forms. These forms are usually budding yeasts, related blastically derived forms such as pseudohyphae, or isotropically enlarged entities known as adiaspores, sclerotic bodies, or spherules. The relatively simple in vivo phenotypes appear to have qualities that enhance their survival and facilitate their dissemination in host tissue. In contrast, most of the same fungi growing saprophytically in nature or under standard in vitro culture conditions tend to produce extensive hyphae with well-differentiated sporulation structures.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ainsworth, G. C., 1955, Pathogenicity of fungi in man and animals, in: Mechanisms of Microbial Pathogenicity (J. W. Howie and A. J. O’Hea, eds.), Cambridge University Press, Cambridge, pp. 242–262.
Alberghina, L., and Sturani, E., 1981, Control of growth and of the nuclear division cycle in Neurospora crassa, Microbiol. Rev. 45:99–122.
Anderson, J. G., 1978, Temperature-induced fungal development, in: The Filamentous Fungi, Vol. 3 (J. E. Smith and D. R. Berry, eds.), John Wiley, New York, pp. 358–375.
Barathova, H., Betina, V., and Ulicky, L., 1977, Regulation of differentiation of the dimorphic fungus Paecilomyces viridis by nitrogen sources, antibiotics and metabolic inhibitors, Folia Microbiol. 22:222–231.
Bartnicki-Garcia, S., 1973, Fundamental aspects of hyphal morphogenesis, in: Microbial Differentiation, Vol. 23 (J. M. Ashworth and J. E. Smith, eds.), Cambridge University Press, Cambridge, pp. 245–267.
Bartnicki-Garcia, S., Ruiz-Herrera, J., and Bracker, C. E., 1979, Chitosomes and chitin synthesis, in: Fungal Walls and Hyphal Growth (J. H. Burnett and A. P. J. Trinci, eds.), Cambridge University Press, Cambridge, pp. 149–168.
Brady, S., 1973, Metabolism, cell walls and morphogenesis, in: Developmental Regulation: Aspects of Cell Differentiation (S. J. Coward, ed.), Academic Press, New York, pp. 107–154.
Cabib, E., 1975, Molecular aspects of yeast morphogenesis, Annu. Rev. Microbiol. 29:191–214.
Cabib, E., 1981, Chitin: Structure, metabolism, and regulation of biosynthesis, in: Encyclopedia of Plant Physiology, New Series, Vol. 13B (W. Tanner and F. A. Loewus, eds.), Springer-Verlag, Berlin, pp. 395–415.
Cabib, E., and Shematek, E. M., 1981, Structural polysaccharides of plants and fungi: Comparative and morphogenetic aspects, in: Biology of Carbohydrates, Vol. 1 (V. Ginsburg, ed.), John Wiley, New York, pp. 51–90.
Cabib, E., Roberts, R., and Bowers, B., 1982, Synthesis of the yeast cell wall and its regulation, Annu. Rev. Biochem. 51:763–793.
Campbell, M. C., and Stewart, J. L., 1980, The Medical Mycology Handbook, John Wiley, New York.
Cochrane, V. W., 1958, Physiology of Fungi, John Wiley, New York.
Cole, G. T., and Samson, R. A., 1983, Conidium and sporangiospore formation in pathogenic microfungi, in: Fungi Pathogenic for Humans and Animals, Part A, Biology (D. H. Howard, ed.), Marcel Dekker, New York, pp. 437–524.
Dabrowa, N., and Howard, D. H., 1983, Blastoconidium germination, in: Fungi Pathogenic for Humans and Animals, Part A, Biology (D. H. Howard, ed.), Marcel Dekker, New York, pp. 525–545.
Emmons, C. W., Binford, C. H., Utz, J. P., and Kwon-Chung, K. J., 1977, Medical Mycology, 3rd ed., Lea and Febiger, Philadelphia.
Garraway, M. O., and Evans, R. C., 1984, Fungal Nutrition and Physiology, John Wiley, New York.
Garrison, R. G., 1983, Ultrastructural cytology of pathogenic fungi, in: Fungi Pathogenic for Humans and Animals, Part A, Biology (D. H. Howard, ed.), Marcel Dekker, New York, pp. 229–321.
Garrison, R. G., and Boyd, K. S., 1973, Dimorphism of Penicillium marniffei as observed by electron microscopy, Can. J. Microbiol. 19:1305–1309.
Hartwell, L. H., 1974, Saccharomyces cerevisiae cell cycle, Bacteriol. Rev. 38:164–198.
Hartwell, L. H., Culotti, H. J., Pringle, J. R., and Reid, B. J., 1974, Genetic control of the cell division cycle in yeast, Science 183:46–51.
Howard, D. H., 1962, The morphogenesis of the parasitic form of the dimorphic fungi, Mycopathol. Mycol. Appl. 18:127–139.
Jansons, V. K., and Nickerson, W. J., 1970a, Induction, morphogenesis, and germination of the chlamydospores of Candida albicans, J. Bacteriol. 104:910–921.
Jansons, V. K., and Nickerson, W. J., 1970b, Chemical composition of chlamydospores of Candida albicans, J. Bacteriol. 104:922–932.
Kulkarni, R. K., and Nickerson, K. W., 1981, Nutritional control of dimorphism in Cera-tocystis ulmi, Exp. Mycol. 5:148–154.
Mariat, F., 1964, Saprophytic and parasitic morphology of pathogenic fungi, in: Microbial Behavior, In Vivo and In Vitro (H. Smith, ed.), Cambridge University Press, Cambridge, pp. 85–111.
Marshall, M., Russo, G., Van Etten, J., and Nickerson, K., 1979, Polyamines in dimorphic fungi, Curr. Microbiol. 22:187–190.
Matsumoto, T., Padhye, A. A., Ajello, L., Standard, P. G., and McGinnis, M. R., 1984, Critical review of human isolates of Wangiella dermatitidis, Mycologia 76:232–249.
McGinnis, M. R., 1980, Laboratory Handbook of Medical Mycology, Academic Press, New York.
McGinnis, M. R., 1983, Chromoblastomycosis and phaeohyphomycosis: New concepts, diagnosis, and mycology, J. Am. Acad. Dermatol 8:1–16.
McNeel, D. J., Kulkarni, R. K., and Nickerson, K. W., 1983, Pleomorphism in Ceratocystis ulmi: Chlamydospore formation, Can. J. Bot. 61:1349–1352.
Mortimer, R. K., and Schild, D., 1980, Genetic map of Saccharomyces cerevisiae, Microbiol. Rev. 44:519–571.
Nishimura, K., and Miyaji, M., 1983, Defense mechanisms of mice against Exophiala der-matitidis infection, Mycopathologia 81:9–21.
Nurse, P., 1981, Genetic analysis of the cell cycle, in: Genetics as a Tool in Microbiology (S. W. Glover and D. A. Hopwood, eds.), Cambridge University Press, London, pp. 291–314.
Park, D., 1982, Inorganic nitrogen nutrition and yeast-mycelial dimorphism in Aureobasidium pullulans, Trans. Br. Mycol. Soc. 81:168–172.
Park, D., 1984, Low pH and the development of large cells in Aureobasidium pullulans, Trans. Br. Mycol. Soc. 82:717–720.
Perkins, D. D., Radford, A., Newmeyer, D., and Bjorkman, M., 1982, Chromosomal loci of Neurospora crassa, Microbiol. Rev. 46:426–570.
Pringle, J. R., and Hartwell, L. H., 1981, The Saccharomyces cerevisiae cell cycle, in: Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance (J. N. Strathern, E. W. Jones, and J. R. Broach, eds.), Cold Spring Harbor Laboratory, New York, pp. 97–142.
Rippon, J. W., 1980, Dimorphism in pathogenic fungi, Crit. Rev. Microbiol 8:49–97.
Rippon, J. W., 1982, Medical Mycology: The Pathogenic Fungi and Pathogenic Actinomy-cetes, 2nd ed., W. B. Saunders, Philadelphia.
Romano, A. H., 1966, Dimorphism, in: The Fungi: An Advanced Treatise, Vol. 2 (G. C. Ainsworth and A. S. Sussman, eds.), Academic Press, New York, pp. 181–209.
Scherr, G. H., and Weaver, R. H., 1953, The dimorphism phenomena in yeasts, Bacteriol. Rev. 17:51–92.
Scott, W. A., 1976, Biochemical genetics of morphogenesis in Neurospora, Annu. Rev. Microbiol. 30:85–104.
Sheckman, R., and Novick, P., 1982, The secretory process and yeast cell-surface assembly, in: Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, (J. N. Strathern, E. W. Jones, and J. R. Broach, eds.), Cold Spring Harbor Laboratory, New York, pp. 361–398.
Stewart, P. R., and Rogers, P. J., 1978, Fungal dimorphism: A particular expression of cell wall morphogenesis, in: The Filamentous Fungi, Vol. 3 (J. E. Smith and D. R. Berry, eds.), John Wiley, New York, pp. 164–196.
Szaniszlo, P. J., Jacobs, C. W., and Geis, P. A., 1983, Dimorphism: Morphological and biochemical aspects, in: Fungi Pathogenic for Humans and Animals, Part A, Biology (D. H. Howard, ed.), Marcel Dekker, New York, pp. 323–436.
Thorner, J., 1981, Pheromonal regulation of development in Saccharomyces cerevisiae, in: Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance (J. N. Strathern, E. W. Jones, and J. R. Broach, eds.), Cold Spring Harbor Laboratory, New York, pp. 143–180.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Szaniszlo, P.J. (1985). An Introduction to Dimorphism among Zoopathogenic Fungi. In: Szaniszlo, P.J., Harris, J.L. (eds) Fungal Dimorphism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4982-2_1
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4982-2_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4984-6
Online ISBN: 978-1-4684-4982-2
eBook Packages: Springer Book Archive