Control of Mitochondrial Respiration
The control of the rate of respiration within cells is a complex process, central to metabolism, and exhibiting several different types of control at different levels of the overall process. The aim of this chapter is to outline some general principles of control in metabolic pathways and recent approaches to describing control; this is followed by a brief review of those steps, in the respiratory pathway of rat liver mitochondria, which are thought to be important in control; finally some experimental work is presented concerning the control of respiration by the proton motive force (Δp), and control of Δp by cation permeabilities.
KeywordsProton Motive Force Irreversible Thermodynamic Primary Pathway Cation Permeability Control Strength
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