Control of Mitochondrial Respiration

  • Guy Brown
Part of the NATO ASI Series book series (NSSA, volume 91)


The control of the rate of respiration within cells is a complex process, central to metabolism, and exhibiting several different types of control at different levels of the overall process. The aim of this chapter is to outline some general principles of control in metabolic pathways and recent approaches to describing control; this is followed by a brief review of those steps, in the respiratory pathway of rat liver mitochondria, which are thought to be important in control; finally some experimental work is presented concerning the control of respiration by the proton motive force (Δp), and control of Δp by cation permeabilities.


Proton Motive Force Irreversible Thermodynamic Primary Pathway Cation Permeability Control Strength 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Azzone, G.F., Pozzan, T., Massari, S. and Bragadin, M., 1978, Biochim. Biophys. Acta, 501: 296.PubMedCrossRefGoogle Scholar
  2. Brown, G. and Brand, M., 1984, Biochem. J., In Press.Google Scholar
  3. Clark, A.J., Cotton, N.P.J. and Jackson, J.B., 1983, Eur. J. Biochem., 130: 575.PubMedCrossRefGoogle Scholar
  4. Davis, E.J. and Lumeng, L., 1975, J. Biol. Chem., 250: 2275.Google Scholar
  5. Davis, R.J. and Martin, B.R., 1982, Biochem. J., 206: 611.PubMedGoogle Scholar
  6. Di Virgilio, F., Pozzan, M. and Azzone, G.F., 1981, Eur. J. Biochem., 177: 225.Google Scholar
  7. Doussiere, E.J., Ligeti, E., Brandolin, G. and Vianais, P.V., 1984 Biochim. Biophys. Acta, 776: 492.Google Scholar
  8. Denton, R.M. and Hughes, W.A., 1978, Int. J. Biochem., 9: 545.PubMedCrossRefGoogle Scholar
  9. Gutman, M., 1980, Biochim. Biophys. Acta, 594: 53.PubMedGoogle Scholar
  10. Hansford, R.G., 1980, Curr. Topic. Bioenerg., 10: 217.Google Scholar
  11. Harris, E.J., Hofer, M.P. and Pressman, B.C., 1967, Biochemistry, 6: 1348.PubMedCrossRefGoogle Scholar
  12. Heinrich, R. and Rapoport, T.A., 1974a, Eur. J. Biochem., 42: 89.PubMedCrossRefGoogle Scholar
  13. Heinrich, R. and Rapoport, T.A., 1974b, Eur. J. Biochem., 42: 97.PubMedCrossRefGoogle Scholar
  14. Kacser, H. and Burns, J.A., 1973, in “Rate Control of Biological Processes”, P.D. Davies, ed., Cambridge University Press, London.Google Scholar
  15. Katchalsky, A. and Curran, P.K., 1967, in “Non-Equilibrium Thermodynamics in Biophysics, Harvard University Press, Cambridge, Mass.Google Scholar
  16. Massari, S., Frigeri, L. and Azzone, G.F., 1972, J. Membrane Biol., 9: 71.CrossRefGoogle Scholar
  17. Nicholls, D.G., 1974, Eur. J. Biochem., 50: 305.PubMedCrossRefGoogle Scholar
  18. O’Shea, P.S., Thelen, S., Petrone, G. and Azzi, A., 1984, FEBS Lett., 172: 103.CrossRefGoogle Scholar
  19. Owen, C.S. and Wilson, D.F., 1974, Arch. Biochem. Biophys., 161: 581.PubMedCrossRefGoogle Scholar
  20. Palmieri, F., Cisternino, M. and Quagliariello, E., 1967, Biochim. Biophys. Acta, 143: 625.PubMedCrossRefGoogle Scholar
  21. Pietrobon, D., Azzone, G.F. cnd Walz, D., 1981, Eur. J. Biochem., 117: 389.PubMedCrossRefGoogle Scholar
  22. Pietrobon, D., Zoratti, M., Azzone, G.F., Stucki, J.W. and Walz, D., 1982, Eur. J. Biochem., 127: 483.PubMedCrossRefGoogle Scholar
  23. Soboll, S., Seitz, H.J., Seis, H., Ziegler, B. and Socholz, R., 1984, Biochem. J., 220: 371.PubMedGoogle Scholar
  24. Stucki, J.W., 1980, Eur. J. Biochem., 109: 257.PubMedCrossRefGoogle Scholar
  25. Stucki, J.W., 1983, Biophys. Chem., 18: 111.PubMedCrossRefGoogle Scholar
  26. Stucki, J.W., Compiani, M. and Caplan, S.R., 1983, Biophys. Chem., 18: 101.PubMedCrossRefGoogle Scholar
  27. Sugdena M.C. and Williomson, D.H., 1982, in “Metabolic Compartmentation”, H. Sies, ed., Academic Press.Google Scholar
  28. Tager, J.M., Wanders, R.J.A., Groen, A.K., Kunz, W., Bohnensack, R., Kurter, U., Letko, G., Bohme, G., Duszynski, J. and Wojtczak, L., 1983, FEBS Lett., 151: 1.PubMedCrossRefGoogle Scholar
  29. Tischler, M.E., Friedrichs, D., Coil, K. and Williamson, J.R., 1977, Arch. Biochem. Biophys., 184: 222.PubMedCrossRefGoogle Scholar
  30. Vignais, P.V., 1976, Biochim. Biophys. Acta, 456: 1.PubMedGoogle Scholar
  31. Westerhoff, H.V., Melandri, B.A., Venturoli, G., Azzone, G.F. and Kell, D.B., 1984, FEBS Lett., 165: 1.PubMedCrossRefGoogle Scholar
  32. Williamson, J.R., Cooper, R.H. and Hoek, J.B., 1981, Biochim. Biophys. Acta, 639: 242.Google Scholar
  33. Wilson, D.F., Owen, C.S. and Holian, A., 1977, Arch. Biochem. Biophys., 182: 749.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Guy Brown
    • 1
  1. 1.Department of BiochemistryUniversity of CambridgeCambridgeUK

Personalised recommendations