Mechanisms of Membrane Lipid Peroxidation

  • Larry G. McGirr
  • Peter J. O’Brien
Part of the NATO ASI Series book series (NSSA, volume 91)


Lipid peroxidation is associated with CCl4-induced hepatotoxicity and various pathological changes associated with the toxicity of some metals, herbicides, drugs, carcinogens, photosensitizers and ozone or NO2. It has also been associated with atheroschlerosis, tumorigenesis and metastases, red cell disorders, inflammation, burns, eye cataracts, skin disorders, neurological disturbances, lung fibrosis, aging, etc. Dietary antioxidants and metal chelators are often protective. However, it remains to be proven whether lipid peroxidation is a direct cause of these toxic effects rather than a consequence (1–8).


Xanthine Oxidase Methyl Linoleate Lipid Hydroperoxide Hydroxyl Radical Formation Initiate Lipid Peroxidation 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Larry G. McGirr
    • 1
  • Peter J. O’Brien
    • 1
  1. 1.Department of BiochemistryMemorial University of NewfoundlandSt. John’sCanada

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