Characterisation of the Nadph — Dependent Superoxide — Generating Oxidase of Phagocytic Leukocytes

  • John F. Parkinson
  • Andrew R. Cross
  • Owen T. G. Jones
Part of the NATO ASI Series book series (NSSA, volume 91)


Phagocytic leukocytes play a major role as part of the immune system in providing protection against infection. As part of their microbicidal activity, neutrophils, the most abundant blood phagocytes, convert molecular oxygen to highly reactive and toxic derivatives such as the superoxide anion, \({{O}_{2}}^{\overline{\centerdot }}\), hydrogen peroxide, H2O2, hypochlorite, OCl, the hydroxyl radical, OH , and possibly singlet oxygen, 1O2, (1).


NADPH Oxidase Human Neutrophil Methyl Viologen Chronic Granulomatous Disease Oxidase Complex 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • John F. Parkinson
    • 1
  • Andrew R. Cross
    • 1
  • Owen T. G. Jones
    • 1
  1. 1.Department of Biochemistry The Medical SchoolUniversity of BristolBristolUK

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