Mycotoxins as Carcinogens

  • Amin M. Hussain
Part of the Basic Life Sciences book series


Fungi which contaminate food and feed products produce toxic metabolites under favourable conditions, thus posing a serious health problem. A variety of mycotoxins are produced by different fungi, but aflatoxins have been investigated more extensively. Varied reports are available on the production of aflatoxins by different species of Aspergillus and Penicillium; however, A. flavus and A. parasiticus have the greatest capacity and appear to be the primary sources of aflatoxins. Preformed mycotoxins are ingested by man through the consumption of vegetable and animal products (milk, meat, etc.). Factors affecting toxicity include species, age, sex, and nutrition. Evidence from animal experiments provides enough information to indicate that most of the mycotoxins are carcinogens.


Ergot Alkaloid Kojic Acid Aflatoxin Production Penicillic Acid Sweet Clover 
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  1. Allcroft, R., and Carnaghan, R. B. A., 1962, Groundnut toxicity: Aspergillus flavus toxin (aflatoxin) in animal products (preliminary communication), Vet. Record, 74:863–864.Google Scholar
  2. Allcroft, R., and Carnaghan, R. B. A., 1963, Groundnut toxicity: An examination for toxin in human food products from animals fed toxic groundnut meal, Vet. Record, 75:259–263.Google Scholar
  3. Alpert, M. E., Hutt, M. S. R., and Davidson, C. S., 1968, Hepatoma in Uganda: A study in geographic pathology, Lancet, 1:1265–1267.PubMedCrossRefGoogle Scholar
  4. Basappa, S. C., Jayaraman, A., Sreenivasamurthy, V., and Parpia, H. A. B., 1967, Effect of B-group vitamins and ethyl alcohol on aflatoxin production by Aspergillus oryzae, Indian J. Exptl. Blol., 5:262–263.Google Scholar
  5. Burnside, J. E., Sippel, W. L., Forgacs, J., Carll, W. T., Atwood, M. B., and Doll, E. R., 1957, A disease of swine and cattle caused by eating moldy corn, II. Experimental production with pure cultures of molds, Am. J. Vet. Res., 18:817–824.PubMedGoogle Scholar
  6. De Iongh, H., Vles, R. O., and van Pelt, J. G., 1964, Milk of mammals fed an aflatoxin-containing diet, Nature, 202:466–467.CrossRefGoogle Scholar
  7. Detroy, R. W., Lillehoj, E. B., and Ciegler, A., 1971, In: “Microbial Toxins,” Vol. VI, A. Ciegler, S. Kadis, and S. J. Ajl, eds., Academic Press, London, pp. 3–178.Google Scholar
  8. Dickens, F., Jones, H. E. H., and Waynforth, H. B., 1966, Oral, subcutaneous and intratracheal administration of carcinogenic lactones and related substances: The intratracheal administration of cigarette tar in the rat, Brit. J. Cancer, 2:134–144.CrossRefGoogle Scholar
  9. Diener, U. L., and Davis, N. D., 1969, in: “Aflatoxin,” L. A. Goldblatt, ed., Academic Press, New York, p. 16.Google Scholar
  10. Drobotko, V. G., 1946, Stachybotryotoxicosis: a new disease of horses and humans, Amer. Rev. Soviet Med., 2:238–242.Google Scholar
  11. Dunham, L. J., and Bailar, J. C., 1968, World maps of cancer mortality rates and frequency ratios, J. Natl. Cancer Inst., 41:155–203.PubMedGoogle Scholar
  12. Eppley, R. M., 1968, Screening method for zearalenone, aflatoxin and ochratoxin, J. Assoc. Offic. Anal. Chemists, 51:74–78.Google Scholar
  13. FAO-WHO, 1966, Mycotoxins in food, Report No. 7, Joint FAO-WHO Expert Committee on Nutrition, Rome.Google Scholar
  14. Forgacs, J., and Carll, W. T., 1955, Preliminary mycotoxic studies of the haemorrhagic disease in poultry, Vet. Med., 50:172.Google Scholar
  15. Hanssen, E., 1969, Schädigung von Lebensmitteln durch Aflatoxin B1, Naturwissenschaften, 56:90.PubMedCrossRefGoogle Scholar
  16. Hartley, R. D., Nesbitt, B. F., and O’Kelly, J., 1963, Toxic metabolites of Aspergillus flavus, Nature, 198:1056–1058.CrossRefGoogle Scholar
  17. Hesseltine, C. W., Shotwell, O. L., Ellis, J. J., and Stubblefield, R. D., 1966, Aflatoxin formation by Aspergillus flavus, Bacteriol. Rev., 30:795–805.PubMedGoogle Scholar
  18. Hodges, F. A., Zust, J. R., Smith, H. R., Nelson, A. A., Armbrecht, B. H., and Campbell, A. D., 1964, Mycotoxins: aflatoxin isolated from Penicillium puberulum, Science, 145:1439.PubMedCrossRefGoogle Scholar
  19. Holzapfel, C. W., Steyn, P. S., and Purchase, I. F. H., 1966, Isolation and structure of aflatoxins M1 and M2, Tetrahedron Letters, 25:2799–2803.PubMedCrossRefGoogle Scholar
  20. Hutter, R. V. P., and Collins, H. S., 1962, The occurrence of opportunistic fungus infections in a cancer hospital, Lab. Invest., 11:1035–1045.Google Scholar
  21. Iqbal, A., Qureshi, A. R., Qureshi, M. J., Nasir, M. A., and Yaqub, M., 1976, Determination of aflatoxins in some stored grains, Pak. J. Sci. Res., 20:50–55.Google Scholar
  22. Jones, B. D., 1972, Methods of aflatoxin analysis, Report C-70, pp. 1–57, Tropical Product Institute, London.Google Scholar
  23. Kinosita, R., and Shikata, T., 1965, in: “Mycotoxins in Foodstuffs,” G. N. Wogan, ed., M.I.T. Press, Cambridge, Massachusetts, pp. 111–132.Google Scholar
  24. Kraybill, H. F., and Shimkin, M. B., 1964, Carcinogenesis related to foods contaminated by processing and fungal metabolites, Advance Cancer Res., 8:191–246.PubMedCrossRefGoogle Scholar
  25. Kulik, M. M., and Holaday, C. E., 1966, Aflatoxin: a metabolic product of several fungi, Mycopathol. Mycol. Appl., 30:137–140.PubMedCrossRefGoogle Scholar
  26. Miller, M. W., 1961, “The Pfizer Handbook of Microbial Metabolites,” McGraw-Hill, New York, 772 pages.Google Scholar
  27. Mislivec, P. B., Hunter, J. H., and Tuite, J., 1968, Assay for aflatoxin production by the genera Aspergillus and Penicillium, Appl. Microbiol., 16:1053–1055.PubMedGoogle Scholar
  28. Payet, G. M., Cros, J., Quenum, C., Sankale, M., and Moulanier, M., 1966, Deux observations d’enfants ayant consommé de facon prolongée des farines souillées par Aspergillus flavus, Presse Med., 74:649–651.Google Scholar
  29. Pons, W. A., Jr., and Goldblatt, L. A., 1965, The determination of aflatoxins in cottonseed products, J. Am. Oil Chemists’ Soc, 42:471–475.CrossRefGoogle Scholar
  30. Robinson, P., 1967, Infantile cirrhosis of the liver in India, Clin. Pediat., 6:57–62.PubMedCrossRefGoogle Scholar
  31. Saito, M., Enomoto, M., and Tatsuno, T. T., 1971, in: “Microbial Toxins,” Vol. VI, A. Ciegler, S. Kadis, and S. J. Ajl, eds., Academic Press, London, pp. 299–380.Google Scholar
  32. Scheel, L. D., Perone, V. B., Larkin, R. L., and Kupel, R. E., 1963, The isolation and characterization of two phototoxic furanocoumarins (psoralens) from diseased celery, Biochemistry, 2:1127–1131.PubMedCrossRefGoogle Scholar
  33. Schofield, F. W., 1924, Damaged sweet clover: the causes of a new disease in cattle simulating haemorrhagic septicemia and Black leg, J. Am. Vet. Med. Assoc., 64:553–575.Google Scholar
  34. Schroeder, H. W., and Verrett, M. J., 1969, Production of aflatoxin by Aspergillus wentii Wehmer, Can. J. Microbiol., 15:895–898.PubMedCrossRefGoogle Scholar
  35. Scott, P. M., van Walbeek, W., and Forgacs, J., 1967, Formation of aflatoxins by Aspergillus ostianus Wehmer, Appl. Microbiol., 15:945.PubMedGoogle Scholar
  36. Sippel, W. L., Burnside, J. E., and Atwood, M. B., 1953, A disease of swine and cattle caused by eating moldy corn, Proceedings of the 90th Annual Meeting of the American Veterinary Medicine Association, Toronto, Canada, pp. 174-181.Google Scholar
  37. Tung, T. C., and Ling, K. H., 1968, Study of aflatoxin of foodstuffs in Taiwan, J. Vitaminol. (Kyoto), 14:48–52.CrossRefGoogle Scholar
  38. van Walbeek, W., Scott, P. M., and Thatcher, F. S., 1968, Mycotoxins from food-borne fungi, Can. J. Microbiol., 14:131–137.PubMedCrossRefGoogle Scholar
  39. Wilson, B. J., Teer, P. A., Barney, G. H., and Blood, F. R., 1967, Relationship of aflatoxin to epizootics of toxic hepatitis among animals in southern United States, Am. J. Vet. Res., 28:1217–1230.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Amin M. Hussain
    • 1
  1. 1.Nuclear Institute for Agriculture and BiologyFaisalabadPakistan

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