A Fortran Program for the Construction of Selby-Olson Tables
Several mutagenicity tests exist in which, due to the relatively large experimental effort involved, a decision about the mutagenic potential of a tested compound has to be based on experimental data with one exposure alone. This is true, for example, for the specific locus test (Russell et al., 1981a) and the spot test in the mouse (Russell et al., 1981b), as well as for most of the Drosophila tests for sex-linked recessive lethals, translocations, or for loss and gain of chromosomes. Selby and Olson (1981) have developed methods and criteria which permit a decision about whether mutation-rate data indicate a positive, negative, or inconclusive result, provided a well established and stable historical control is available. They proposed a multiple-decision procedure which provides for a general conceptual framework for the whole decision process. Applying this procedure to a particular experiment and a particular historical control leads to a table (from here on called the Selby-Olson table) which, for a given experimental result, permits conclusions to be drawn without any further calculations. Since the Selby-Olson decision tables have to be recalculated every time additional data have been added to the historical control, we felt that it might be useful for many workers in the field to have a simple, interactive computer program at hand which allows quick and easy updating of Selby-Olson tables. These can be a preselection of any sample size region in which one may be interested. In this paper we describe the practical use of such a program in connection with mutagenicity testing experiments using Drosophila melanogaster.
KeywordsHistorical Control Control Frequency FORTRAN Program Output Line Continue Type
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