Advertisement

A Fortran Program for the Construction of Selby-Olson Tables

  • F. E. Würgler
  • H. Frei
Part of the Basic Life Sciences book series

Abstract

Several mutagenicity tests exist in which, due to the relatively large experimental effort involved, a decision about the mutagenic potential of a tested compound has to be based on experimental data with one exposure alone. This is true, for example, for the specific locus test (Russell et al., 1981a) and the spot test in the mouse (Russell et al., 1981b), as well as for most of the Drosophila tests for sex-linked recessive lethals, translocations, or for loss and gain of chromosomes. Selby and Olson (1981) have developed methods and criteria which permit a decision about whether mutation-rate data indicate a positive, negative, or inconclusive result, provided a well established and stable historical control is available. They proposed a multiple-decision procedure which provides for a general conceptual framework for the whole decision process. Applying this procedure to a particular experiment and a particular historical control leads to a table (from here on called the Selby-Olson table) which, for a given experimental result, permits conclusions to be drawn without any further calculations. Since the Selby-Olson decision tables have to be recalculated every time additional data have been added to the historical control, we felt that it might be useful for many workers in the field to have a simple, interactive computer program at hand which allows quick and easy updating of Selby-Olson tables. These can be a preselection of any sample size region in which one may be interested. In this paper we describe the practical use of such a program in connection with mutagenicity testing experiments using Drosophila melanogaster.

Keywords

Historical Control Control Frequency FORTRAN Program Output Line Continue Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Fisher, R. A., 1948, “Statistical Methods for Research Workers,” Oliver and Boyd, Edinburgh, 354 pages.Google Scholar
  2. Gocke, E., Eckhardt, K., King, M.-T., and Wild, D., 1982, Some statistical aspects of spontaneous sex-linked recessive lethal mutations in Drosophila, Mutat. Res., 104:239–242.PubMedCrossRefGoogle Scholar
  3. Russell, L. B., Selby, P. B., Von Halle, E., Sheridan, W., and Valcovic, L., 1981a, The mouse specific-locus test with agents other than radiations. Interpretation of data and recommendations for future work, Mutat. Res., 86:329–354.PubMedGoogle Scholar
  4. Russell, L. B., Selby, P. B., Von Halle, E., Sheridan, W., and Valcovic, L., 1981b, Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work, Mutat. Res., 86:355–379.PubMedGoogle Scholar
  5. Selby, P. B., and Olson, W. H., 1981, Methods and criteria for deciding whether specific-locus mutation-rate data in mice indicate a positive, negative, or inconclusive result, Mutat. Res., 83:403–418.CrossRefGoogle Scholar
  6. Würgler, F. E., Woodruff, R. C., Valencia, R., Von Halle, E., Graf, U., and Zimmering, S., 1985, Heritable reciprocal translocations in Drosophila melanogaster. A methodological review, Mutat. Res. (in press).Google Scholar

Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • F. E. Würgler
    • 1
  • H. Frei
    • 1
  1. 1.Institute of ToxicologySwiss Federal Institute of Technology and University of ZürichSchwerzenbach near ZürichSwitzerland

Personalised recommendations