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Molecular Studies on the Cytomegaloviruses of Mice and Men

  • D. H. Spector
Part of the Genetic Engineering: Principles and Methods book series (GEPM, volume 7)

Abstract

The cytomegaloviruses (CMV) are among the largest animal viruses, and on the basis of morphological and biochemical characteristics, they have been classified in the herpesvirus group. The hallmark of this group of viruses is their ability to cause persistent and latent infections. In the last 20 years, human CMV (HCMV), in particular, has gained recognition as its association with a broad spectrum of diseases and potential oncogenic capacity has been appreciated (for review see 1–4). Congenital infection with HCMV represents the most frequent viral infection of newborns and involves approximately 1% of all live births. Although infection in immunocompetent children and adults is usually asymptomatic, it can result in pneumonia, hepatitis, heterophile-negative mononucleosis, chorioretinitis or encephalitis. HCMV is also a serious problem for individuals who have been immunocompromised either therapeutically or as the result of disease. In these individuals, primary infection with CMV or reactivation of latent virus often leads to interstitial pneumonia and death.

Keywords

Herpes Simplex Virus Acquire Immune Deficiency Syndrome HCMV Infection EcoRI Fragment Junction Fragment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • D. H. Spector
    • 1
  1. 1.Department of BiologyUniversity of CaliforniaSan Diego, La JollaUSA

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