The Role of Mechanistic Data in Dose-Response Modeling
A critical issue in carcinogenic dose-response modeling involves the functional form of the relationship between the two distinct measures of exposure denoted by the terms administered dose and delivered dose. Administered dose refers to the external measures of exposure that are directly controlled in laboratory studies of toxicity. For inhalation studies, it typically denotes the concentration of a test chemical in the inhalation chamber air. In contrast, delivered dose refers to internal measures of exposure, such as the quantity or concentration of the biologically active form of a test chemical that is present in specific target tissue components. It is this latter measure, the delivered dose, that is presumed to be the direct causative variable in mechanistic descriptions of the carcinogenic process at the cellular and molecular levels.
KeywordsVinyl Chloride Covalent Binding Mucociliary Clearance Mechanistic Data Formaldehyde Exposure
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