The present workshop is the second of two coordinated conferences on mechanisms of carcinogenesis. The first meeting highlighted the molecular mechanisms common to radiation and chemical agents. Here we will place greater emphasis on epidemiological considerations and on dose-response models used in risk assessment to extrapolate from experimental data obtained at high doses to the effects from long-term, low-level exposures. Nevertheless, we feel so strongly that the sorting out of biologically realistic dose-response models must follow from mechanistic insight that we will open Session I with reports from the NCI symposium/workshop. It is my charge to deal with common molecular mechanisms; Michael Fry will be the rapporteur on cellular and animal models.


Chemical Carcinogen Chemical Carcinogenesis Extrapolation Model dNTP Pool Weak Mutagen 
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References Given in This Report

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References Given by Speakers: Oxy-Radical Chemistry: Radical Lifetimes; Autoxidation; Induced Decompositions of Peroxides — W. A. Pryor

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References Given by Speakers: Physiological Targets of Oxy Radicals and Carcinogenesis — L.J. Marnett

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References Given by Speakers: The Role of DNA Alkylation in Chemical Carcinogenesis — P. Brookes

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References Given by Speakers: Ionizing Radiation Damage — J. F. Ward

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References Given by Speakers: The Role of Chromosomal Damage by Indirect Action in Carcinogenesis — P. Cerutti

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References Given by Speakers: Role of DNA Repair in Radiation and Chemical Induced Carcinogenesis — M. C. Paterson

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References Given by Speakers: Multiple Primary Targets for Induced Carcinogenesis — R. H. Haynes

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References Given by Speakers: Chromosome Rearrangements in Cancer — R. J. Preston

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References Given by Speakers: Promotion/Progression and Involvement of Non-DNA Targets — T.J. Slaga

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References Given by Speakers: Modifiers of Mutagenesis and Carcinogenesis — L. W. Wattenberg

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Donald C. Borg
    • 1
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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