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Abstract

The present workshop is the second of two coordinated conferences on mechanisms of carcinogenesis. The first meeting highlighted the molecular mechanisms common to radiation and chemical agents. Here we will place greater emphasis on epidemiological considerations and on dose-response models used in risk assessment to extrapolate from experimental data obtained at high doses to the effects from long-term, low-level exposures. Nevertheless, we feel so strongly that the sorting out of biologically realistic dose-response models must follow from mechanistic insight that we will open Session I with reports from the NCI symposium/workshop. It is my charge to deal with common molecular mechanisms; Michael Fry will be the rapporteur on cellular and animal models.

Keywords

Chemical Carcinogen Chemical Carcinogenesis Extrapolation Model dNTP Pool Weak Mutagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References Given in This Report

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References Given by Speakers: Multiple Primary Targets for Induced Carcinogenesis — R. H. Haynes

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References Given by Speakers: Chromosome Rearrangements in Cancer — R. J. Preston

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References Given by Speakers: Promotion/Progression and Involvement of Non-DNA Targets — T.J. Slaga

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References Given by Speakers: Modifiers of Mutagenesis and Carcinogenesis — L. W. Wattenberg

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Donald C. Borg
    • 1
  1. 1.Medical DepartmentBrookhaven National LaboratoryUptonUSA

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