The Agent Carrier and Transfer Approach to Radiobiological Responses

  • Victor P. Bond
  • Matesh N. Varma
Part of the Basic Life Sciences book series


A conceptually close analogue for evaluating different approaches to the assessment of the average risk to cells exposed to “low-level radiation” can be found in physics. Here a physical target(s) of atomic or nuclear dimensions is exposed in a specified field of incident particles, and the probability of a particle-target encounter, and thus the risk of target transformation, is determined by observing the number of encounters that occur during a given exposure time tE. This approach is described by the simple equation,
$${{\text{N}}_{\text{H}}} = {{\text{N}}_{\text{E}}}\;\phi \;\mathop \sigma \limits^ - ,\;{\text{or}}$$
$${{\text{I}}_{\text{H}}} = \phi \mathop {\sigma ,}\limits^ -$$


Relative Biological Effectiveness Agent Delivery Risk Coefficient Quantal Response Agent Source 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Victor P. Bond
    • 1
  • Matesh N. Varma
    • 1
  1. 1.Brookhaven National LaboratoryUptonUSA

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