Genetic and Epigenetic Aspects of Tumor Progression and Tumor Heterogeneity

  • R. G. Liteplo
  • P. Frost
  • R. S. Kerbel
Part of the Basic Life Sciences book series


It is obvious that in order to reduce the incidence of cancer we need to identify those factors in our environment which may be responsible for the formation of neoplasms. What is not so obvious is that the threat of exposure to mutagens or carcinogens may persist even after a tumor has formed for the reason that these agents can affect the progression of the disease. This is especially important to bear in mind as far as cancer therapy is concerned, since exposure of tumors to radiation and chemicals in the form of radiotherapy and chemotherapy increases dramatically after diagnosis. It is therefore important to ask if exposure to these agents can influence the biological behavior of residual tumor cells. This question is not trivial, since the failure of most therapeutic regimens to “cure” cancer may be related to two important factors which, at least in theory, can be affected by exposure to mutagenic agents.


Thymidine Kinase Tumor Heterogeneity Metastatic Phenotype Tumor Cell Population Ethyl Methanesulphonate 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • R. G. Liteplo
    • 1
  • P. Frost
    • 2
  • R. S. Kerbel
    • 1
  1. 1.Cancer Res. Labs., Dept. PathologyQueen’s Univ.Kingston, Ont., Can.Canada
  2. 2.Dept. MedicineVAH HospitalLong BeachUSA

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