Role of Tumor Promotion in Affecting the Multi-Hit Nature of Carcinogenesis

  • James E. Trosko
  • Chia-cheng Chang
Part of the Basic Life Sciences book series


A variety of radiations and chemicals can induce a wide spectrum of acute and chronic disease states, including cancer, when animals or human beings are acutely exposed to moderate or high levels of these agents. However, with the exception of accidents, exaggerated lifestyles and genetic predispositions, the common real-life situation is one of chronic low-level exposure.


Tumor Promotion Mouse Skin Intercellular Communication Xeroderma Pigmentosum Harderian Gland 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • James E. Trosko
    • 1
  • Chia-cheng Chang
    • 1
  1. 1.Department of Pediatrics and Human DevelopmentMichigan State UniversityEast LansingUSA

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