The Immunochemistry of Monoclonal Antibodies: Studies on One Immunologic Supergene (HLA) with the Products of Another
Since the H-2 and HLA systems were defined and have continued to be described by serologic methods, the introduction of monoclonal antibodies into these areas was an obvious and inevitable development.1 The potential exists for redefining the charts of H-2 public and private specificities and the complex and ever-changing diagrams of HLA cross-reactivities in terms of epitopes defined by panels of monoclonal antibodies. Fundamental questions about the number and arrangement of polymorphic sites could be more rigorously addressed and the involvement of different epitopes in restricting antigen recognition by T cells investigated. At a more practical level it would provide abundant and reliable reagents for assay, localization, and purification of HLA molecules.
KeywordsCell Surface Molecule Univalent Complex Dissociation Rate Constant Switch Variant Antigen Density
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