Abstract
Activation of clones of T cells by the specific antigen to which they are reactive requires that the antigen be processed (i.e., metabolized and displayed on the cell surface) by antigen-presenting cells (APCs; reviewed in Ref. 1). While the macrophage has been the most thoroughly studied of APCs, over the past few years it has been determined that a variety of cell types may function in this capacity. We now know that dendritric cells, B cells, and endothelial and Langerhans cells are all capable of antigen presentation, although this may not be a constitutive property of each cell type.1 The three basic properties that define the APCs are: (1) the ability to process antigen, usually by an endocytic route involving lysosomal function; (2) the expression of class II MHC products (the Ia glycoproteins), in association with which the processed antigenic determinant is recognized by the T-cell antigen receptor; and (3) the production of interleukin 1 (IL-1), which provides a requisite signal during T-cell activation. Antigen-induced activation is accompanied by a series of changes in the resting T cell, paramount among which is the induction of receptors for, and secretion of, interleukin 2 (IL-2). A variety of lymphokines that is important for immune function is also produced by the activated T cell, and one of them, interferon gamma (IFN-γ), plays a key role in macrophage activation. The end result of this antigen-induced activation is the selective proliferation of the antigen-reactive T cells.
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References
Unanue, E. R., Beller, D. I., Lu, C. Y., and Allen, P. M., 1984, Antigen presentation: Comments on its regulation and mechanism, J. Immunol. 132:1–5.
Gery, I., Gershon, R. K., and Waksman, B. H., 1972, Potentiation of the T-lymphocyte response to mitogens. I. The responding cell, J. Exp. Med. 135:128–137.
Luger, T. A., Stadler, B. M., Luger, B. M., Mathieson, B. J., Mage, M., Schmidt, J. A., and Opperheim, J. J., 1982, Murine epidermal cell-derived thymocyte-activity factor resembles murine IL-1, J. Immunol. 128:2147–2152.
Unanue, E. R., and Kiely, J.-M., 1977, Synthesis and secretion of a mitogenic protein by macrophages: Description of a superinduction phenomenon, J. Immunol. 119:925–931.
Calderon, J., Kiely, J.-M., Lefko, J. L., and Unanue, E. R., 1975, The modulation of lymphocyte functions by molecules secreted by macrophages, J. Exp. Med. 142:151–164.
Blyden, G., and Handschumacher, R. E., 1977, Purification and properties of human lymphocyte-activating factor (LAF), J. Immunol. 118:1631–1638.
Gery, I., and Lepe-Zuniga, J. L., 1984, Interleukin 1: Uniqueness of its production and spectrum of activities, Lymphokines 9:109–125.
Economou, J. S., and Shin, H. S., 1978, Lymphocyte-activating factor. I. Generation and phys-icochemical characterization, J. Immunol. 121:1446–1452.
Mizel, S. B., and Mizel, D., 1981, Purification to apparent homogeneity of murine interleukin 1, J. Immunol. 126:834–837.
Mizel, S. B., Dukovich, M., and Rothstein, J., 1983, Preparation of goat antibodies against interleukin 1: Use of an immunoadsorbent to purify interleukin 1, J. Immunol. 131:1834–1837.
Dinarello, C. A., Renfer, L., and Wolff, S. M., 1977, Human leukocytic pyrogen: Purification and development of a radioimmunoassay, Proc. Natl. Acad. Sci. USA 74:4624–4627.
Lachman, L. B., Page, S. O., and Metzger, R. S., 1980, Purification of human interleukin 1, J. Supramol. Struct. 13:457–464.
Schmidt, J. A., 1984, Purification and partial biochemical characterization of normal human interleukin 1, J. Exp. Med. 160:772–787.
Beller, D. I., and Unanue, E. R., 1979, Evidence that thymocytes require at least two distinct signals to proliferate, J. Immunol. 123:2890–2893.
Larsson, E., and Coutinho, A., 1979, On the role of mitogenic lectins in T cell triggering, Nature 280:239–241.
Smith, K. A., Lachman, L. B., Oppenheim, J. J., and Favata, M. F., 1980, The functional relationship of the interleukins, J. Exp. Med. 151:1551–1560.
Hunig, T., Loos, M., and Schimpl, A., 1983, The role of accessory cells in polyclonal T cell activation. I. Both induction of interleukin 2 production and of interleukin 2 responsiveness by Con A are accessory cell dependent, Eur. J. Immunol. 13:1–6.
Beller, D. I., 1984, Functional significance of the regulation of macrophage la expression, Eur. J. Immunol. 14:138–143.
Kurt-Jones, E. A., Beller, D. I., Mizel, S. B., and Unanue, E. R., 1985, Identification of a surface-associated interleukin 1 in macrophages, Proc. Natl. Acad. Sci. USA 80:1204–1208.
Kay, J., Porcelli, S., Tite, J., Jones, B., and Janeway, C. A., Jr., 1983, Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells, J. Exp. Med. 158:836–845.
Howard, M., Mizel, S. B., Lachman, L., Ansel, J., Johnson, B., and Paul, W. E., 1983, Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation, J. Exp. Med. 157:1529–1543.
Farrar, J. J., Koopman, W. J., and Fuller-Bonan, J., 1977, Identification and partial purification of two synergistically acting helper mediators in human mixed leukocyte culture supernatants, J. Immunol. 119:47–54.
Hoffman, M. K., and Watson, J., 1979, Helper T cell-replacing factors secreted by thymus-derived cells and macrophages: Cellular requirements for B cell activation and synergistic properties, J. Immunol. 122:1371–1378.
Staruch, M. J., and Wood, D. D., 1983, The adjuvanticity of interleukin 1 in vivo, J. Immunol. 130:2191–2194.
Prystowsky, M. B., Ely, J. M., Beller, D. I., Eisenberg, L., Goldman, J., Goldwasser, E., Ihle, J., Quintans, J., Remold, H., Vogel, S. N., and Fitch, F. W., 1982, Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes, J. Immunol. 129:2337–2344.
Kelso, A., Glosebrook, A. L., Kanagawa, O., and Brunner, K. D., 1982, Production of macrophage-activating factor by T lymphocyte clones and correlation with other lymphokine activities, J. Immunol. 129:550–556.
Honda, K., Suzuki, R., Matsui, H., Shimizu, Y., and Kumagai, K., 1983, Natural killer (NK) cells as a responder to interleukin 2 (IL-2). II. IL-2-induced interferon-gamma production, J. Immunol. 130:988–992.
Kanase, I., Brooks, C. G., Kusibayashi, K., Olabuenagy, S., Newman, W., Gillis, S., and Henney, C. S., 1983, Interleukin 2 induces interferon-gamma production; Participation of macrophages and NK-like cells, J. Immunol. 131:288–292.
Farrar, W. L., Johnson, H. M., and Farrar, J. J., 1981, Regulation of the production of immune interferon and cytotoxic T lymphoytes by interleukin 2, J. Immunol. 126:1120–1125.
Steeg, P. S., Moore, R. N., Johnson, H. M., and Oppenheim, J. J., 1982, Regulation of murine macrophage Ia antigen expression by a lymphokine with immune interferon activity, J. Exp. Med. 156:1780–1793.
Gray, P. W., and Goeddel, D. V., 1983, Cloning and expression of murine IFN-gamma cDNA, Proc. Natl. Acad. Sci. USA 80:5842–5846.
Gray, P. W., and Goeddel, D. V., 1982, Structure of the human immune interferon gene, Nature 298:859–863.
Lindahl, P., Leary, P., and Gresser, I., 1979, Enhancement of the expression of histocompatibility antigens of mouse lymphoid cells by interferon in vitro, Eur. J. Immunol. 4:779–784.
Roberts, W. K., and Vasil, A., 1982, Evidence for the identity of murine gamma interferon and macrophage-activating factor, J. Interferon Res. 4:519–528.
Schreiber, R. D., Pace, J. L., Russel, S. W., Altman, A., and Katz, D. H., 1983, Macrophage-activating factor produced by a T cell hybridoma: Physicochemical and biosynthetic resemblance to gamma interferon, J. Immunol. 131:826–833.
King, D. P., and Jones, P. P., 1983, Induction of Ia and H-2 antigens on a macrophage cell line by immune interferon, J. Immunol. 131:315–318.
Beller, D. I., and Unanue, E. R., 1981, Regulation of macrophage populations. II. Synthesis and expression of Ia antigens by peritoneal exudate macrophages is a transient event, J. Immunol. 126:263–269.
Scher, M. G., Unanue, E. R., and Beller, D. I., 1982, Regulation of macrophage populations. III. The immunologic induction of exudates rich in la-bearing macrophages is a radiosensitive process, J. Immunol. 128:447–450.
Beller, D. I., Kiely, J.-M., and Unanue, E. R., 1980, Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli, J. Immunol. 124:1426–1432.
Scher, M. G., Beller, D. I., and Unanue, E. R., 1980, Demonstration of a soluble mediator that induces exudates rich in la-positive macrophages, J. Exp. Med. 152:1684–1698.
Calamai, E. G., Beller, D. I., and Unanue, E. R., 1982, Regulation of macrophage populations. IV. Modulation of Ia expression in bone marrow-derived macrophages, J. Immunol. 128:1692–1694.
Beller, D. I., and Ho, K., 1982, Regulation of macrophage populations. V. Evaluation of the control of macrophage Ia expression in vitro, J. Immunol. 129:971–976.
Walker, E. L., Lanier, L., and Warner, N., 1982, Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line, J. Exp. Med. 155:269–272.
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© 1985 Plenum Press, New York
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Beller, D.I. (1985). Interleukin 1, Interferon Gamma, and the Modulation of Macrophage-T-Cell Interactions. In: Springer, T.A. (eds) Hybridoma Technology in the Biosciences and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4964-8_37
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DOI: https://doi.org/10.1007/978-1-4684-4964-8_37
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