A significant technical advance in the field of immunology is the ability to isolate homogeneous and monospecific populations of lymphocytes. Among the several methodologies that have been employed, somatic cell hybridization is proving to be a powerful tool in the isolation and characterization of T-lymphocyte clones. The technique of cell fusion is similar to that used to generate monoclonal antibodies. However, the initial lymphocyte selection as well as the identification and characterization of hybridomas differ considerably. Once derived, the T-cell hybridomas are useful, sometimes uniquely so, for a wide range of applications.


Hybrid Clone Tumor Parent Suppressor Factor Fusion Frequency Helper Factor 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Kenneth L. Rock
    • 1
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA

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