Manipulation of T-Cell Populations to Abrogate Allograft Rejection

  • Charles B. Carpenter


Selective intervention in the afferent or efferent arcs of the immune response in vivo has become a possibility because specific subsets of interacting cells can be identified by monoclonal antibodies directed to surface molecules that relate to specific functions. A subset of cells thus identified can be targeted for destruction, either by opsonization and/or complement-mediated lysis, or by internalization of toxins that have been conjugated to the antibody molecules. Other possibilities relate to the inhibition by specific monoclonal antibodies of cell surface receptors or interaction sites without actually destroying the cell, or to the neutralization of secreted molecules [e.g., interleukin 2 (IL-2) or interferon gamma (IFN-γ)].


Allograft Rejection Renal Allograft Rejection Episode Mixed Lymphocyte Reaction Acute Rejection Episode 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Charles B. Carpenter
    • 1
  1. 1.Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

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