Strategies for Production of Human Monoclonal Antibodies

  • Susan P. C. Cole
  • Danuta Kozbor
  • John C. C. Roder


The potential of monoclonal antibodies (MAbs) as therapeutic agents has now been firmly established.1 While the technology for the production of murine hybridoma MAbs has been refined enormously since it was introduced in 1975,2,3 the technology for generating human MAbs initially lagged behind. However, recent advances now make it reasonable to suggest that it will soon be possible to generate human antibodies with as much success as murine antibodies are presently being produced. In this chapter, current strategies for the production of human MAbs are described.


Human Monoclonal Antibody Tetanus Toxoid Fusion Partner Infectious Mononucleosis Subacute Sclerosing Panencephalitis 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Susan P. C. Cole
    • 1
  • Danuta Kozbor
    • 1
  • John C. C. Roder
    • 1
  1. 1.Department of Microbiology and ImmunologyQueen’s UniversityKingstonCanada

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