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Functional and Structural Interrelationships among the Mac-1, LFA-1 Family of Leukocyte Adhesion Glycoproteins, and their Deficiency in a Novel Heritable Disease

  • Timothy A. Springer
  • Donald C. Anderson

Abstract

Cell surface adherence reactions are of central importance in the immune functions of lymphocytes, monocytes, and granulocytes. Lymphocytes adhere to antigen-presenting macrophages or dendritic cells in the induction of T-lym-phocyte immune responses, and to target cells in cell-mediated killing. Adhesive interactions are fundamental to a wide sprectrum of functions of granulocytes, monocytes, and macrophages. Specific recognition of opsonized microorganisms is facilitated by membrane receptors for IgG and for the third component of complement (C3), which mediate microbe-cell adhesion prior to the triggering of cytoskeletal events leading to endocytosis. Adhesion mediated by IgG (Fc) receptors can also trigger antibody-dependent killing of target cells, independently of endocytosis. In the absence of opsonins, some microorganisms/particles may adhere to granulocytes/monocytes without undergoing ingestion or may be phagocytized inefficiently, depending on the physical properties of the microorganisms.1

Keywords

Chronic Granulomatous Disease Hairy Cell Leukemia Glycoprotein Family Autosomal Recessive Disease33 Structural Interrelationship 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Timothy A. Springer
    • 1
    • 2
  • Donald C. Anderson
    • 3
  1. 1.Laboratory of Membrane ImmunochemistryDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of PathologyHarvard Medical SchoolBostonUSA
  3. 3.Department of PediatricsBaylor College of MedicineHoustonUSA

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