The discovery of the biological importance of norepinephrine (NE) is inextricably tied to the development of the concept of chemical neurotransmission which took place in the 1920s and 1930s. The key figures in the genesis of this revolutionary idea were Loewi, who demonstrated that a substance similar to epinephrine was responsible for the acceleration of the heartbeat produced by sympathetic nerve stimulation, and Cannon, who established that an epinephrinelike substance is the chemical mediator liberated by sympathetic nerve impulses at neuroeffector junctions. Von Euler subsequently identified the substance in question as norepinephrine.


Dorsal Horn Locus Coeruleus Superior Cervical Ganglion Purkinje Neuron Intracellular Recording 


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Michael A. Rogawski

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