The first study of the actons of the excitatory amino acid l-glutamate* on the brain was carried out more than 30 years ago. In 1954, Hayashi found that application of glutamate to the surface of the cerebral cortex evoked strong convulsive activity. A few years later Curtis et al. (1960) demonstrated that microiontophoretic administration of glutamate in the vicinity of spinal neurons of the cat produced intense discharges of action potentials recorded extracellularly.


Excitatory Amino Acid Kainic Acid Ibotenic Acid Olfactory Cortex Excitatory Amino Acid Receptor 
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© Plenum Press, New York 1985

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  • Andrea Nistri

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