Early in this century, histamine (imidazolethylamine) was detected by Sir Henry Dale and his co-workers as a uterine stimulant in extracts of contaminated ergot (Barger and Dale, 1910). In the following years, its potent effects on smooth muscle and its participation in the allergic response were established. Although originally suspected to be the result of bacterial action during putrefaction, the compound was later successfully isolated from several types of fresh tissue and was therefore given the name histamine, which is derived from the Greek word histos for tissue. In 1943, using the guinea pig ileum as bioassay, Kwiatkowski detected histamine in brain and observed that there was a higher concentration in the grey than in the white matter. More sensitive methods for the determination of histamine were subsequently developed, including fluorometric and enzymatic-isotopic assays, but until very recently it has not been possible to directly visualize histaminergic neurons in brain. Thus, histamine has attracted less attention among neurobiologists than other biogenic amines, although evidence that it acts as a neurotransmitter is at least as good (Green, 1970; Green et al., 1978, Schwartz et al., 1985).


Histamine Receptor Medial Forebrain Bundle Histidine Decarboxylase Calcium Spike Histaminergic Neuron 


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© Plenum Press, New York 1985

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  • Helmut L. Haas

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