Mapping the Human Genome Using Restriction Fragment Length Polymorphisms

  • David Botstein


It is a truism that people, like all living organisms, are the products of their heredity, their environmental history, and the interaction between their heredity and their environment. This truism applies, of course, to any pathology that an individual may display. The difficulty with the truism is that the degree to which hereditary and environmental influences can contribute to disease states is variable in the extreme. Some disease states are entirely of environmental origin; in most instances, the genetic contribution to, let us say, a broken leg is negligible. Other disease states are demonstrably hereditary; the environmental contribution to beta-thalassemia is likewise negligible. Most disease states, however, fall into the spectrum in between; evidence for hereditary as well as environmental influences can be found.


Restriction Fragment Length Polymorphism Down Syndrome Disease Gene Linkage Phase RFLP Locus 
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Copyright information

© Aubrey Milunsky and George J. Annas 1985

Authors and Affiliations

  • David Botstein
    • 1
  1. 1.Massachusetts Institute of TechnologyCambridgeUSA

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