Abstract
Unlike B lymphocytes which have a single major function, the secretion of antibody, T lymphocytes mediate a variety of immunologic and nonimmunologic functions. Human T cells can be divided into several distinct cell types or subsets, which interact through cell surface molecules with one another, monocytes, and B cells to generate and regulate immunity. In addition, many T-cell functions appear to be mediated wholly or in part by soluble immunoregulatory factors, or lymphokines, at least as numerous as the subsets from which they are derived. Thus, an understanding of immune function in man depends on a thorough knowledge of the structure and actions both of T-cell surface molecules and T-cell-derived lymphokines.
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References
Cantor, H., and Boyse, E. A. 1977, Regulation of cellular and humoral immunity by T cell subclasses, Cold Spring Harbor Symp. Quant. Biol. 41: 23.
Damle, N. K., and Engleman, E. G., 1983, Immunoregulatory T cell circuits in man. Alloantigenprimed inducer cells activate alloantigen-specific suppressor T cells in the absence of the initial antigenic stimulus, J. Exp. Med. 158: 159.
Damle, N. K., Mohagheghpour, N., Hansen, J. A., and Engleman, E. G., 1983, Alloantigenspecific cytotoxic and suppressor T lymphocytes are derived from phenotypically distinct precursors, J. Immunol. 131: 2296.
Damle, N. K., Mohagheghpour, N., and Engleman, E. G., 1984a, Soluble antigen primed inducer T cells activate antigen specific suppressor T cells in the absence of antigen pulsed accessory cells. Phenotypic definition of suppressor, inducer and effector cells, J. Immunol. 132: 644.
Damle, N. K., Mohagheghpour, N., and Engleman, E. G., 1984b, Activation of antigen-specific suppressor T lymphocytes in man involves dual recognition of self class I MHC molecules and Leu 4/T3 associated structures on the surface of inducer T lymphocytes, J. Immunol. 133: 1235.
Damle, N. K., Mohagheghpour, N., Kansas, G., Fishwild, D., and Engleman, E. G., 1985, Immunoregulatory T cell circuits in man. Identification of a distinct T cell subpopulation of helper/inducer lineage that amplifies the development of alloantigen-specific suppressor T cells, J. Immunol. 134: 235.
Engleman, E. G., Benike, C. J., Grumet, F. C., and Evans, R. L., 1981a, Activation of human T lymphocyte subsets: Helper and suppressor/cytotoxic T cells recognize and respond to distinct histocompatibility antigens, J. Immunol. 127: 2124.
Engleman, E. G., Benike, C. J., Glickman, E., and Evans, R. L., 1981b, Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphócyte subpopulations block the mixed leukocyte reaction in man, J. Exp. Med. 154: 193.
Engleman, E. G., Benike, C. J., Metzler, C., Gatenby, P. A., and Evans, R. L., 1983, Blocking of human T lymphocyte functions by anti-Leu-2 and anti-Leu-3 antibodies: Differential inhibition of proliferation and suppression, J. Immunol. 130: 2623.
Evans, R. L., Wall, D. W., Platsoucas, C. D., Siegal, F. P., Fikrig, S. M., Testa, C. M., and Good, R. A., 1981, Thymus-dependent membrane antigens in man. Inhibition of cell-mediated lympholysis by monoclonal antibodies to the TH2 antigen, Proc. Natl. Acad. Sci. USA 78: 544.
Falkoff, R. J. M., Muragudin, A., Hong, J. X., Butler, J. L., Dinarello, C. A., and Francis, A. S., 1983, The effects of interleukin 1 on human B cell activation and proliferation, J. Immunol. 131: 801.
Fathman, C. G., and Engleman, E. G., 1985, T cell lines and hybrids in mouse and man, in: Handbook of Experimental Immunology, 4th ed. ( D. M. Weir, L. A. Herzenberg, C. C. Blackwell, and L. A. Herzenberg, eds.), Blackwell, London, In press.
Fathman, C. G., and Fitch, F. W. (eds.), 1982, Isolation, Characterization and Utilization of T lymphocyte Clones, Academic Press, London.
Finke, J. H., Sharma, S. D., and Scott, J. W., 1981, Generation of alloreactive cytotoxic T lymphocytes: Production of T cell and monocyte helper factors on addition to ILI and IL2 by peritoneal cells from mice immunized to Lisifrie monocytogenes, J. Immunol. 127: 125.
Foung, S. K. H., Sasaki, D., Grumet, F. C., and Engleman, E. G., 1982, Production of functional human T-T hybridomas in selection medium lacking aminopterin and thymidine, Proc. Natl. Acad. Sci. USA 79: 7494.
Gatenby, P. A., Kotzin, B. L., and Engleman, E. G., 1981, Induction of immunoglobulin-secreting cells in the human autologous mixed leukocyte reaction. Regulation by helper and suppressor lymphocyte subsets defined with monoclonal antibodies, J. Immunol. 127: 2130.
Gatenby, P. A., Kansas, G. S., Xian, C. Y., Evans, R. L., and Engleman, E. G., 1982, Dissection of immunoregulatory subpopulations of T lymphocytes within the helper and suppressor sub-lineages in man, J. Immunol. 129: 1997.
Germain, R. N., and Benacerraf, B., 1981, A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression, Scand. J. Immunol. 13: 1.
Kappler, J. W., Skidmore, B., White, J., and Marrack, P., 1981, Antigen-inducible H-2 restricted interleukin 2 producing T cell hybridomas, J. Exp. Med. 153: 1198.
Köhler, G., and Milstein, C., 1975, Continuous cultures of fused cells secreting antibody of predefined specificity, Nature 256: 495.
Kotzin, B. L., Benike, C. J., and Engleman, E. G., 1981, Induction of immunoglobulin-secreting cells in the allogeneic MLR. Regulation by helper and suppressor lymphocyte subsets in man, J. Immunol. 127: 931.
Krensky, A. M., Reiss, C. S., Wier, J. M., Strominger, J. L., and Burakoff, Si., 1982, Long-term human cytolytic T cell lines allospecific for HLA-D6 antigen are OKT4+, Proc. Natl. Acad. Sci. USA 79: 2365.
Lakow, E., Tsoukas, C. D., Vaughan, J. H., Altman, A., and Carson, D. A., 1983, Human T cell hybridomas for Epstein—Barr virus infected B lymphocytes, J. Immunol. 130: 169.
Marrack, P., Hannam, C., Harris, M., Haskin, K., Kubo, R., Pigeon, M., Shimonkevitz, R., White, J., and Kappier, J., 1983, Antigen-specific major histocompatibility complex-restricted T cell receptors, Immunol. Rev. 76: 131.
Meuer, S. C., Schlossman, S. F., and Reinherz, E. L., 1982a, Clonal analysis of human cytotoxic T lymphocytes T4+ and T8 + effector cells recognize products of different histocompatibility regions, Proc. Natl. Acad. Sci. USA 79: 4395.
Meuer, S. C., Hussey, R. E., Hodgdon, J. C., Hercend, T., and Schlossman, S. F., 1982b, Surface structures involved in target recognition by human cytotoxic T lymphocytes, Science 218: 471.
Meuer, S. C., Acuto, O., Hussey, R. E., Hodsdon, J. C., Fitzgerald, K. A., Schlossman, and Reinherz, E. L., 1983, Evidence for the T3-associated 90k heterodimer as the T cell antigen receptor, Nature 303: 808.
Mitsuya, H., Guo, H.-G., Cossman, J., Megson, M., Reitz, M. S., and Broder, S., 1984, Functional properties of antigen-specific T cells injected by human T-cell leukemia-lymphoma virus (HTL°-t), Science 225: 1484.
Mohagheghpour, N., Benike, C. J., Kansas, G. S., Bieber, C., and Engleman, E. G., 1983, Activation of antigen specific suppressor T cells in the presence of cyclosporin requires interactions between T cells of inducer and suppressor lineage, J. Clin, Invest. 72: 2092.
Moller, G. (ed.), 1982, Interleukins and lymphocyte activation, Immunol. Rev. 63.
Moller, G. (ed.), 1984, B cell growth and differentiation factors, Immunol. Rev. 78.
Okada, M., Sakaguchi, N., Yoshimura, N., Hara, H., Shimuzu, K., Yoshida, N., Yoshizaki, K., Kishimoto, S., Yamamura, Y., and Kishimoto, T., 1983, B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and their synergism in B cell proliferation, J. Exp. Med. 157: 583.
Reinherz, E. L., Kung, P. C., Goldstein, G., and Schlossman, S. F., 1979, Separation of functional subsets of human T cells by a monoclonal antibody, Proc. Natl. Acad. Sci. USA 76: 4061.
Reinherz, E. L., Kung, P. C., Goldstein, G., and Schlossman, S. F., 1980, A monoclonal antibody reactive with the human cytotoxic/supressor T cell subset previously defined by a heteroantiserum termed TH2, J. Immunol. 124: 1301.
Sansoni, P., Silverman, E. D., Khan, M. M., Melmon, K. L., and Engleman, E. G., 1985, Immunoregulatory T cells in man. Histamine-induced suppressor T cells are derived from a Leu 2± (T8+) subpopulation distinct from that which gives rise to cytotoxic T cells, J. Clin. Invest. 75: 650.
Webb, D. R., Kapp, J. A., and Pierce, C. W., 1983. The biochemistry of antigen-specific T cell factors, Annu. Rev. Immunol. 1: 423.
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Coutre, S., Foung, S.K.H., Engleman, E.G. (1985). Human T-Lymphocyte Subsets and T-T Hybridomas. In: Engleman, E.G., Foung, S.K.H., Larrick, J.W., Raubitschek, A.A. (eds) Human Hybridomas and Monoclonal Antibodies. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4949-5_18
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DOI: https://doi.org/10.1007/978-1-4684-4949-5_18
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