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Human—Human Hybridomas in the Study of Immunodeficiencies

  • Kathleen A. Denis
  • Randolph Wall
  • Andrew Saxon

Abstract

The majority of B-lymphocyte hybridomas, whether rodent—rodent, rodent—human, or human—human, are produced to use the resulting antibodies as tools. These monoclonal antibody products of hybridomas have been used successfully to purify proteins, define antigenic structures on normal and malignant cells, characterize viruses and microorganisms, and numerous other related tasks (Kennett et al., 1980; Yelton and Scharff, 1981). Certainly one of the major goals of human—human hybridoma technology is to use human monoclonal antibodies in the diagnosis and therapy of a wide range of human disease states.

Keywords

Heavy Chain Peripheral Blood Lymphocyte Immunoglobulin Heavy Chain Heavy Chain Gene Common Variable Immunodeficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Kathleen A. Denis
    • 1
  • Randolph Wall
    • 1
  • Andrew Saxon
    • 2
  1. 1.Departments of Microbiology and ImmunologyUCLA School of MedicineLos AngelesUSA
  2. 2.Department of MedicineUCLA School of MedicineLos AngelesUSA

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