Human—Human Hybridomas in the Study of Immunodeficiencies
The majority of B-lymphocyte hybridomas, whether rodent—rodent, rodent—human, or human—human, are produced to use the resulting antibodies as tools. These monoclonal antibody products of hybridomas have been used successfully to purify proteins, define antigenic structures on normal and malignant cells, characterize viruses and microorganisms, and numerous other related tasks (Kennett et al., 1980; Yelton and Scharff, 1981). Certainly one of the major goals of human—human hybridoma technology is to use human monoclonal antibodies in the diagnosis and therapy of a wide range of human disease states.
KeywordsHeavy Chain Peripheral Blood Lymphocyte Immunoglobulin Heavy Chain Heavy Chain Gene Common Variable Immunodeficiency
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