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Design and Production of Human Monoclonal Antibodies to Human Cancers

  • Mark C. Glassy
  • Harold H. Handley
  • Ivor Royston

Abstract

Central questions of the tumor immunologist pertain to the type and nature of antigens appearing in the malignant state and methods used to detect them. Monoclonal antibody (MAb) technology (Köhler and Milstein, 1975) provides investigators an opportunity to study virtually any immunogenic molecule with exact precision and has been successful in detecting human tumor antigens (Boss et al., 1983). Recently, hybridoma technology has been extended to the production of human MAbs (Olsson and Kaplan, 1980; Schlom et al., 1980; Croce et al., 1980; Glassy et al., 1981, 1983a; Sikora and Phillips, 1981; Edwards et al., 1982) and is being used to study human tumor antigens.

Keywords

Tumor Antigen Human Monoclonal Antibody Benign Prostatic Hypertrophy Prostate Carcinoma Cell Fusion Frequency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Mark C. Glassy
    • 1
    • 2
  • Harold H. Handley
    • 1
    • 2
  • Ivor Royston
    • 1
    • 2
  1. 1.Cancer CenterUniversity of CaliforniaSan DiegoUSA
  2. 2.Veterans Administration Medical CenterSan DiegoUSA

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