Human Hybridomas and Monoclonal Antibodies

The Biology of Cell Fusion
  • Jerry W. Shay


In this review I will cover, from a cell biologist’s perspective, the biology of cell fusion and how the information derived from the field may be applicable to the production of human monoclonal antibodies. I will describe the development of the hybridoma technology, the advantages and disadvantages of making and using monoclonal antibodies, the methods and limitations of making human monoclonal antibodies, the freezing and thawing of hybridomas, and end with a discussion of chromosome segregation in cell hybrids.


Spleen Cell Myeloma Cell Thymidine Kinase Cell Fusion Human Monoclonal Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jerry W. Shay
    • 1
  1. 1.Department of Cell BiologyUniversity of Texas Health Science Center at DallasDallasUSA

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