Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase
There is considerable interest in the lipoxygenation of mitochondrial membranes because of the inhibitory influence this process can have on mitochondrial activities such as oxidative phosphorylation (Vladimirov et al., 1980). In addition, mitochondrial lipid peroxidation has been associated with several important pathological conditions. These include hypoxia and postischemic reperfusion (Hillered and Ernster, 1983), aging (Nohl et al., 1978), and the cytotoxicity of many chemicals as well as UV or ionizing radiation (Vladimirov et ai., 1980).
KeywordsMitochondrial Membrane Mitochondrial Respiration Intact Mitochondrion Swell Mitochondrion Malate Glutamate
Unable to display preview. Download preview PDF.
- Fiskum, G., 1984, Physiological aspects of mitochondrial calcium transport, in: Metal Ions in Biological Systems, Vol. 17: Calcium and Its Role in Biology (H. Sigel, ed.), Marcel Dekker, New York, pp. 187–214.Google Scholar
- Fiskum, G., Bryant, R.W., Pease, A., and Bailey, J.M., 1983, Influence of reticulocyte lipoxygenase and 15-HETE on mitochondrial energy coupling, Fed. Proc. 42:2251.Google Scholar
- Hughes, H., Smith, C.V., Horning, E.C, and Mitchell, J.R., 1983, High performance liquid chromatography and gas chromatography-mass spectrometry determination of specific lipid per-oxidation products in vivo, Anal. Biochem. 130:431–436.Google Scholar
- Rapoport, S. M., Schewe, T., Wiesner, R., Halangk, W., Ludwig, P., Janicke-Hohne, M., Tannert, C, Hiebsch, C, and Klatt, D., 1979, The lipoxygenase of reticulocytes: Purification, characterization and biological dynamics of the lipoxygenase; its identity with the respiratory inhibitors of the reticulocyte, Eur. J. Biochem. 96:545–561.PubMedCrossRefGoogle Scholar
- Schewe, T., Halangk, W., Hiebsch, C, and Rapoport, S., 1977, Degradation of mitochondria by cytosolic factors in reticulocytes, Acta Biol. Med. Germ. 36:363–372.Google Scholar