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Lipoxygenation of Mitochondrial Membranes by Reticulocyte Lipoxygenase

  • Gary Fiskum
  • Robert W. Bryant
  • Chow-Eng Low
  • Andrew Pease
  • J. Martyn Bailey
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

There is considerable interest in the lipoxygenation of mitochondrial membranes because of the inhibitory influence this process can have on mitochondrial activities such as oxidative phosphorylation (Vladimirov et al., 1980). In addition, mitochondrial lipid peroxidation has been associated with several important pathological conditions. These include hypoxia and postischemic reperfusion (Hillered and Ernster, 1983), aging (Nohl et al., 1978), and the cytotoxicity of many chemicals as well as UV or ionizing radiation (Vladimirov et ai., 1980).

Keywords

Mitochondrial Membrane Mitochondrial Respiration Intact Mitochondrion Swell Mitochondrion Malate Glutamate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Gary Fiskum
    • 1
  • Robert W. Bryant
    • 1
  • Chow-Eng Low
    • 1
  • Andrew Pease
    • 1
  • J. Martyn Bailey
    • 1
  1. 1.Department of BiochemistryGeorge Washington University School of Medicine and Health SciencesUSA

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