Glutathione Transferases Catalyzing Leukotriene C Synthesis and Metabolism of Leukotrienes C4 and E4in Vivo and in Vitro
Glutathione transferases constitute a group of enzymes that catalyze several reactions involving glutathione (Mannervik, 1985). Their main function, according to current concepts, is to detoxify and accelerate the excretion of certain xenobiotic compounds (Chasseaud, 1979) by catalyzing the conjugation of glutathione with these electro-philic substrates. In addition, glutathione transferases also catalyze other reactions (e. g., peroxidase and isomerase reactions). We have recently reported (Mannervik et al., 1984) that six basic glutathione transferases from rat liver cytosol (Mannervik and Jensson, 1982) catalyze the conversion of LTA4 or its methyl ester to LTC4. One of the enzymes was a considerably more efficient catalyst of the reaction than the remaining five.
KeywordsChronic Granulomatous Disease Compound VIII Glutathione Transferase Raney Nickel Monomethyl Ester
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