Relationship between Drug Absorption, Inhibition of Cyclooxygenase and Lipoxygenase Pathways, and Development of Gastric Mucosal Damage by Nonsteroidal Antiinflammatory Drugs in Rats and Pigs
Many authors have provided evidence for an association between inhibition of prostaglandin (PG) synthesis by the nonsteroidal and antiinflammatory (NSAI) drugs and their propensity to elicit gastric mucosal damage (Boughton-Smith and Whittle, 1983; Peskar et al., 1981, 1984; Rainsford and Willis, 1982; Rainsford, 1984; Rainsford et al., 1984). By comparison, relatively little is known about the relationship between the inhibition by NSAI drugs of the synthesis of various eicosanoids to (1) the time-dependent changes induced in the various mucosal cells by these drugs and (2) the pattern of drug uptake into the gastric mucosa. Furthermore, it is not known if the different NSAI drugs with varying potency as PG synthesis inhibitors have the capacity to elicit damage to the mucosal cells in the same way. These aspects are important in order to determine the precise role that inhibition of the synthesis of the different eicosanoids has in the induction of pathological changes in different cells by ulcerogenic NSAI drugs. The studies reported here are an attempt to provide some information in answer to these questions.
KeywordsGastric Mucosa Parietal Cell Mucosal Cell Inhibit Platelet Aggregation Prostaglandin Production
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