Abstract
The carcinogenic process can be experimentally divided into stages; this is advantageous in developing an understanding of the molecular changes in each stage that are essential for the development of neoplasias. One of the best-studied multistage models is the mouse skin (Slaga et al., 1980a,b,c). Initiation is the result of a single application of a carcinogen, most commonly 7,12-dimethylbenz[a]anthracene, at a dose that causes no tumors. The second stage, promotion, results from the repetitive treatment with a tumor promoter such as 12-O-tetradecanoylphorbol-13-acetate (TPA). Of all the biochemical and morphological responses of the epidermis to TPA, the most important and relevant appear to be the induction of ornithine decarboxylase, the induction of dark cells, hyperplasia, and the development of an inflammatory state (Slaga et al., 1980b, c, d).
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References
Birnboim, H. C., 1983, Importance of DNA strand break in tumor promotion, in: Radioprotectors and Anticarcinogens (O. F. Nygaard and M. G. Simic, eds.), Academic Press, New York, pp. 539–556.
Bors, W., Saran, M., and Michel, C., 1983, Assays of oxygen radicals: Methods and mechanisms, in: Superoxide Dismutase, Vol. II (L. W. Oberley, ed.), CRC Press, Boca Raton, FL, pp. 31-63.
Bresnick, E., Meunier, P., and Lamden, M., 1979, Epidermal prostaglandins after topical application of a tumor promoter, Cancer Lett. 7:121.
Cerutti, P. A., Amstad, P., and Emerit, I., 1983, Tumor promoter phorbol-myristate-acetate induces membrane mediated chromosomal damage, in: Radioprotectors and Anticarcinogens (O. F. Nygaard and G. Simic, eds.). Academic Press, New York, pp. 527-538.
Fischer, S. M., 1984, The role of prostaglandins in tumor production, in: Mechanisms of Tumor Promotion, Vol. II, Tumor Promotion and Skin Carcinogenesis (T. J. Slaga, ed.), CRC Press, Boca Raton, FL. pp. 113-126.
Fischer, S.M., and Adams, L.A.. 1985, Tumor promoter-induced chemiluminescence in mouse epidermal cells is inhibited by several inhibitors of arachidonic acid metabolism, Cancer Res. 45:1–6.
Fischer, S.M., Gleason, G.L., Bohrman, J.S., and Slaga, T.J., 1980a, Prostaglandin modulation of phorbol ester skin tumor promotion, Carcinogenesis 1:245–248.
Fischer, S.M., Gleason, G.L., Bohrman, J.S., and Slaga, T.J., 1980b, Prostaglandin enhancement of skin tumor initiation and promotion, Adv. Prostaglandin Thromboxane Res. 6:517–522.
Fischer, S.M., Gleason, G.L., Mills, G.D., and Slaga, T.J., 1980c, Indomethacin enhancement of TPA tumor promotion in mice, Cancer Lett. 10:343–350.
Fischer, S.M., Mills, G.D., and Slaga, T.J., 1982, Inhibition of mouse skin tumor promotion by several inhibitors of arachidonic acid metabolism, Carcinogenesis 3:1243–1245.
Furstenberger, G., and Marks, F., 1982, Studies on the role of prostaglandins in the induction of cell proliferation and hyperplasia and in tumor promotion in mouse skin, in: Carcinogenesis, Vol. 7: Carcinogenesis and Biological Effects of Tumor Promoters (E. Hecker, N. E. Fusenig, W. Kunz, F. Marks, and H. W. Thielman, eds.), Raven Press, New York, pp. 325-330.
Goldstein, B.D., Witz, G., Amoruso, M., Stone, D.S., and Troll, W., 1981, Stimulation of human polymorphonuclear leukocyte Superoxide anion radical production by tumor promoters, Cancer Lett. 11:257–262.
Janoff, A., Klassen, A., and Troll, W., 1970, Local vascular changes induced by the cocarcinogen phorbol myristate acetate, Cancer Res. 30:2568–2571.
Kensler, T.W., and Trush, M.A., 1981, Inhibition of phorbol-ester stimulated chemiluminescence in human polymorphonuclear leukocytes by retinoic acid and 5,6-epoxy-retinoic acid, Cancer Res. 41:216–222.
Kensler, T.W., and Trush, M.A., 1983, Inhibition of oxygen radical metabolism in phorbol ester-mediated polymorphonuclear leukocytes by an antitumor promoting copper complex with Superoxide dismutase mimetic activity, Biochem. Pharmacol. 32:3485–3487.
Kensler, T.W., Bush, D.M., and Kozumbo, W.J., 1983, Inhibition of tumor promotion by a biomimetic Superoxide dismutase, Science 221:75–77.
Klein-Szanto, A.J.P., Major, S.M., and Slaga, T.J., 1980, Induction of dark keratinocytes by 12-O-tetradecanoylphorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency, Carcinogenesis 1:399–406.
Kozumbo, W.J., Seed, J.L., and Kensler, T.W., 1983, Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate, Cancer Res. 43:2555–2559.
Lupulescu, A., 1978, Enhancement of carcinogenesis by prostaglandins in male albino Swiss mice, J. Natl. Cancer Inst. 61:97–106.
Schwartz, J.A., Viaje, A., Slaga, T.J., Yuspa, S.H., Hennings, H., and Lichti, U., 1977, Fluocinolone acetonide: A potent inhibitor of mouse skin tumor promotion and epidermal DNA-synthesis, Chem. Biol. Interact. 17:331–347.
Shamberger, R.J., 1972, Increase of peroxidation in carcinogenesis, J. Natl. Cancer Inst. 48:1491–1497.
Slaga, T. J., Fischer, S. M., Viaje, A., Berry, D. L., Bracken, W. M., LeClerc, S., and Miller, D. L., 1978, Inhibition of tumor promotion by anti-inflammatory agents: An approach to the biochemical mechanism of promotion, in: Carcinogenesis, Vol. 2, Mechanisms of Tumor Promotion and Cocarcinogenesis (T. J. Slaga, A. Sivak, and R. K. Boutwell, eds.), Raven Press, New York, pp. 173-195.
Slaga, T.J., Fischer, S.M., Nelson, K., and Gleason, G.L., 1980a, Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion, Proc. Natl. Acad. Sci. U.S.A. 77:3659–3663.
Slaga, T.J., Klein-Szanto, A.J.P., Fischer, S.M., Weeks, C.E., Nelson, K., and Major, S., 1980b, Studies on the mechanism of action of anti-tumor promoting agents: Their specificity in two-stage promotion, Proc. Natl. Acad. Sci. U.S.A. 77:2251–2254.
Slaga, T. J., Fischer, S. M., Weeks, C. E., and Klein-Szanto, A. J. P., 1980c, Multistage chemical carcinogenesis, in: Biochemistry of Normal and Abnormal Epidermal Differentiation (M. Seije and I. A. Bernstein, eds.), University of Tokyo Press, Tokyo, pp. 193-218.
Slaga, T.J., Klein-Szanto, A.J.P., Triplett, L.L., and Yotti, L.P., 1981, Skin tumor-promoting activity of benzoyl peroxide, a widely used free radical-generating compound, Science 213:1023–1025.
Slaga, T. J., Fischer, S. M., Weeks, C. E., Nelson, K., Mamrack, M., and Klein-Szanto, A. J. P., 1982, Specificity and mechanisms of promoter inhibitors in multistage promotion, in: Carcinogenesis, Vol. 7: Carcinogenesis and Biological Effects of Tumor Promoters (E. Hecker, N. E. Fusenig, W. Kunz, F. Marks, and H. W. Thielman, eds.), Raven Press, New York, pp. 19-34.
Solanki, V., Rana, R.S., and Slaga, T.J., 1981, Diminution of mouse epidermal Superoxide dismutase and catalase activities by tumor promoters, Carcinogenesis 2:1141–1146.
Trush, M.A., Wilson, M.E., and Van Dyke, K., 1978, The generation of chemiluminescence by phagocytic cells, Methods Enzymol. 57:462–494.
Verma, A.K., Rice, H.M., and Boutwell, R.K., 1977, Prostaglandins and skin tumor promotion inhibition of tumor promoter induced ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis, Biochem. Biophys. Res. Commun. 79:1160–1166.
Verma, A.K., Ashendel, C.L., and Boutwell, R.K., 1980, Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate, Cancer Res. 40:308–315.
Witz, G., Goldstein, B.D., Amoruso, M., Stone, D.S., and Troll, W., 1980, Retinoid inhibition of Superoxide anion radical production by human polymorphonuclear leukocytes stimulated with tumor promoters, Biochem. Biophys. Res. Commun. 97:883–888.
Yotti, L.P., Chang, C.C., and Trosko, J.E., 1979, Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter, Science 207:1089–1091.
Yuspa, S.H., and Harris, C.C., 1974, Altered differentiation of mouse epidermal cells treated with retinyl acetate in vitro, Exp. Cell Res. 86:95–105.
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Fischer, S.M., Adams, L.M. (1985). Inhibitors of Arachidonic Acid Metabolism Inhibit Tumor-Promoter-Stimulated Chemiluminescence in Murine Keratinocytes. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, and Lipoxins. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4946-4_58
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