Comparative Biochemistry of Lipoxygenase Inhibitors

  • Robert W. Egan
  • Paul H. Gale
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


This chapter describes some studies on the mechanism of 5-lipoxygenase regulation and inhibition and then presents an overview of lipoxygenase inhibitors that are active against intact-cell, broken-cell, and purifed enzymes from a variety of sources. Although a large number of lipoxygenase inhibitors have been reported, many of these are rather nonselective. Some of the lack of selectivity may result from a common mechanism of lipoxygenase inhibition by antioxidants and redox regulation. It is, therefore, not sufficient to define specificity against broken-cell enzymes. A truly diagnostic agent must be specific in cellular systems and in vivo to be of utility in defining the role of lipoxygenases in pathophysiology.


Arachidonic Acid Supernatant Fraction Lipoxygenase Inhibitor Nordihydroguaiaretic Acid Lipoxygenase Product 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Robert W. Egan
    • 1
  • Paul H. Gale
    • 1
  1. 1.Merck Institute for Therapeutic ResearchRahwayUSA

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