Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway

  • Norbert Gualde
  • James S. Goodwin
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Oxygenated arachidonic acid derivatives are metabolites that issue from both the cyclooxygenase and the lipoxygenase pathways and act as important local immunoregulators. The cyclooxygenase products, especially the prostaglandins (PGs), are currently being investigated with regard to their role in the immune response. Inhibition of lymphocyte activity is the main function of prostaglandins as immunoregulators, and PGE2 may be viewed as a macrophage messenger for an inhibitory signal to lymphocytes (Goodwin and Ceuppens, 1983). It is likely that PGE2 is a biological mediator of a physiological negative feedback mechanism following stimulation by antigens (Goodwin et al., 1983).


Arachidonic Acid Suppressor Cell Mouse Peritoneal Macrophage Arachidonic Acid Metabolite Lipoxygenase Pathway 


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Norbert Gualde
    • 1
  • James S. Goodwin
    • 2
  1. 1.Immunology and Biochemistry Research UnitSchool of MedicineLimoges CédexFrance
  2. 2.Department of MedicineMedical College of WisconsinMilwaukeeUSA

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