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Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway

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Prostaglandins, Leukotrienes, and Lipoxins

Abstract

Oxygenated arachidonic acid derivatives are metabolites that issue from both the cyclooxygenase and the lipoxygenase pathways and act as important local immunoregulators. The cyclooxygenase products, especially the prostaglandins (PGs), are currently being investigated with regard to their role in the immune response. Inhibition of lymphocyte activity is the main function of prostaglandins as immunoregulators, and PGE2 may be viewed as a macrophage messenger for an inhibitory signal to lymphocytes (Goodwin and Ceuppens, 1983). It is likely that PGE2 is a biological mediator of a physiological negative feedback mechanism following stimulation by antigens (Goodwin et al., 1983).

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Author information

Authors and Affiliations

  1. Immunology and Biochemistry Research Unit, School of Medicine, 87032, Limoges Cédex, France

    Norbert Gualde

  2. Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, 53226, USA

    James S. Goodwin

Authors
  1. Norbert Gualde
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  2. James S. Goodwin
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Editor information

Editors and Affiliations

  1. The George Washington University Medical Center, Washington, D.C., USA

    J. Martyn Bailey

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Gualde, N., Goodwin, J.S. (1985). Induction of Suppressor T Cells in Vitro by Arachidonic Acid Metabolites Issued from the Lipoxygenase Pathway. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, and Lipoxins. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4946-4_54

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  • DOI: https://doi.org/10.1007/978-1-4684-4946-4_54

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4948-8

  • Online ISBN: 978-1-4684-4946-4

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