Eicosanoid Precursor Fatty Acids in Plasma Phospholipids and Arachidonate Metabolism in Polymorphonuclear Leukocytes in Asthma
The cysteine-containing leukotrienes C4, D4, and E4 as well as leukotriene B4, a dihydroxy acid, are formed from arachidonic acid via the Ca2+-dependent 5-lipoxygenase pathway (Borgeat et al., 1983). They have been considered to be mediators of immediate hypersensitivity reactions. Sensitized human lung is capable of releasing leukotrienes when exposed to a specific antigen (Dahlén et al., 1983), and LTC4 and LTD4 have been shown to be potent bronchoconstrictors both in vivo (Holroyde et al., 1981) and in vitro (Dahlén et al., 1980). Leukotriene B4 is a potent chemokinetic and chemotactic substance (Ford-Hutchinson et al., 1980). Also, stimulated human polymorphonuclear leukocytes (PMNL) are capable of producing substantial amounts of 5-lipoxygenase products, as well as other lipoxygenase and cyclooxygenase metabolites (Borgeat and Samuelsson, 1979; Samuelsson, 1983).
KeywordsArachidonic Acid Asthmatic Patient Polymorphonuclear Leukocyte Plasma Phospholipid Healthy SUbjects
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