Differential Effects of Leukotriene B4 and Its Analogues on Suppressor and Helper Cell Function
Recent studies have demonstrated that leukotrienes (LTs), in addition to their myotropic properties, also strongly affect several leukocyte functions. For instance, LTB4 was shown to stimulate neutrophil aggregation (Bass et al., 1981), chemokinesis (Ford-Hutchinson et al., 1980; Palmer et al., 1980), chemotaxis (Palmer et al., 1980), degranulation (Showell et al., 1982a), hexose transport (Bass et al., 1981), and cation fluxes (Molski et al., 1981).
KeywordsHelper Cell Suppressor Cell Hexose Transport Lipoxygenase Product Neutrophil Degranulation
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- Molski, T.F.P., Naccache, P.H., Borgeat, P., and Sha’afi, R.I., 1981, Similarities in the mechanisms by which formyl-methionyl-leucyl-phenylalanine, arachidonic acid and leukotriene B4 increase calcium and sodium influxes in rabbit neutrophils, Biochem. Biophys. Res. Commun. 103:227–232.PubMedCrossRefGoogle Scholar
- Rola-Pleszczynski, M., and Sirois, P., 1983, Leukotrienes as immunoregulators, in: Leukotrienes and other Lipoxygenase Products (P. J. Piper, ed.), Wiley and Sons, London, pp. 234–240.Google Scholar
- Rola-Pleszczynski, M., Gagnon, L., and Sirois, P., 1984a, Natural cytotoxic cell activity enhanced by leukotriene B4: Modulation by cyclooxygenase and lipoxygenase inhibitors, in: Icosanoids and Cancer (A. Crastes de Paulet, ed.), Raven Press, New York, pp. 235–240.Google Scholar