Release of Leukotrienes B4 and D4 by the Anaphylactic Guinea Pig Lung in Vitro
The lung possesses several enzymic systems for the metabolism of arachidonic acid (Samuelsson et al., 1975; Hammarström, 1983). Among these, the 5-lipoxygenase has recently received considerable attention since some of its products, the leukotrienes (LTs), may play critical roles in inflammation (Samuelsson, 1982; Lewis and Austen, 1981) and immediate hypersensitivity reactions (Holroyde et al., 1981; Dahlén et al., 1980). Indeed, leukotriene B4 (LTB4) was shown to be a potent chemotactic substance towards polymorphonuclear leukocytes (PMNL) (Ford-Hutchison et al., 1980), and leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) were found to have strong myotropic activity on smooth muscles of the respiratory tract (Drazen et al., 1980; Hedqvist et al., 1980; Lewis et al., 1980).
KeywordsLung Perfusate Antigen Challenge Eicosatetraenoic Acid Absorbance Unit Full Scale Mouse Mastocytoma Cell
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