Release of Leukotrienes B4 and D4 by the Anaphylactic Guinea Pig Lung in Vitro

  • Hassan Salari
  • Pierre Borgeat
  • Pierre Braquet
  • Yvon Brousseau
  • Pierre Sirois
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The lung possesses several enzymic systems for the metabolism of arachidonic acid (Samuelsson et al., 1975; Hammarström, 1983). Among these, the 5-lipoxygenase has recently received considerable attention since some of its products, the leukotrienes (LTs), may play critical roles in inflammation (Samuelsson, 1982; Lewis and Austen, 1981) and immediate hypersensitivity reactions (Holroyde et al., 1981; Dahlén et al., 1980). Indeed, leukotriene B4 (LTB4) was shown to be a potent chemotactic substance towards polymorphonuclear leukocytes (PMNL) (Ford-Hutchison et al., 1980), and leukotrienes C4 (LTC4), D4 (LTD4), and E4 (LTE4) were found to have strong myotropic activity on smooth muscles of the respiratory tract (Drazen et al., 1980; Hedqvist et al., 1980; Lewis et al., 1980).


Lung Perfusate Antigen Challenge Eicosatetraenoic Acid Absorbance Unit Full Scale Mouse Mastocytoma Cell 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Hassan Salari
    • 1
  • Pierre Borgeat
    • 1
  • Pierre Braquet
    • 2
  • Yvon Brousseau
    • 3
  • Pierre Sirois
    • 3
  1. 1.Groupe de Recherche sur les Leucotriènes, Laboratoire d’Endocrinologie MoléculaireCentre Hospitalier de l’Université LavalQuébecCanada
  2. 2.I. H. B. Research LaboratoriesLe Plessis-RobinsonFrance
  3. 3.Département de PédiatrieCentre Hospitalier Universitaire, Université de SherbrookeSherbrookeCanada

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