Abstract
Mitogen activation of human peripheral blood lymphocytes (HPBL) occurs as a consequence of several early membrane events. One of the earliest is the Ca2+ -dependent stimulation of guanylate cyclase (Coffey et al., 1981). Experiments with the T-cell mitogens phytohemagglutinin (PHA), concanavalin A (Con A), and phorbol myristate acetate (PMA) suggested that phospholipase and lipoxygenase activation are important in the sequence of early membrane events leading to guanylate cyclase stimulation, cGMP accumulation, and DNA synthesis (Coffey and Hadden,1981, 1983a,b). Cyclooxygenase (Coffey et al., 1981) and thromboxane synthetase activities (Gordon et al., 1981) were not found to be essential for mitogenesis.
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Coffey, R.G., Hadden, J.W. (1985). Stimulation of Lymphocyte Guanylate Cyclase by Arachidonic Acid and HETEs. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, and Lipoxins. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4946-4_48
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