Biochemical Cascade Involved in Mast Cell Activation for Mediator Release
Mast cells and basophil granulocytes bear specific receptors for IgE, which bind IgE molecules with high affinity, and the reactions of cell-bound IgE antibodies with multivalent antigen initiate the release of a variety of preformed and newly generated mediators such as histamine and leukotrienes (Ishizaka and Ishizaka, 1975). Mast cells also secrete these inflammatory mediators in response to various nonspecific stimuli. These mediators cause allergic disorders in both experimental animals and men. Among the various mast-cell-derived mediators, oxidative products of arachidonic acid (AA) have drawn much attention in recent years. It has been shown that rat peritoneal mast cells and human lung mast cells, but not bone-marrow-derived mouse mast cells, generate prostaglandin D2 (PGD2) through the cyclooxygenase pathway. Conversely, mouse bone-marrow-derived mast cells, as well as human lung mast cells generate primarily leukotriene C4 (LTC4) through the lipoxygenase pathway, but peritoneal mast cells do not (Lewis et al., 1981; Peters et al., 1984; Razin et al., 1983). Leukotrienes cause contraction of airway smooth muscles and are considered to be the most potent bronchoconstrictors in human asthma.
KeywordsMast Cell Histamine Release Phosphatidic Acid Mediator Release Human Mast Cell
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