Membrane Events and Guanylate Cyclase Activation in Mitogen-Stimulated Lymphocytes

  • John W. Hadden
  • Elba M. Hadden
  • Ronald G. Coffey
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The lymphocyte has provided an important model for the study of the early biochemical events associated with the initiation of cellular proliferation. Resting lymphocytes (G0 or restricted G1 phase), as obtained from human peripheral blood, can be induced in large numbers to undergo clonal proliferation using a variety of mitogens. The two most commonly employed plant lectin mitogens are phytohem-agglutinin (PHA) and concanavalin A (Con A). The initiation process is characterized by rapid, saturable binding of the lectin to cellular receptors (<30 min), followed by a series of cellular events involving probably three cell types.


Lymphocyte Proliferation Cyclic Nucleotide Guanylate Cyclase Lymphocyte Activation Phorbol Myristate Acetate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • John W. Hadden
    • 1
  • Elba M. Hadden
    • 1
  • Ronald G. Coffey
    • 1
  1. 1.Program of Immuno-pharmacologyUniversity of South Florida Medical CollegeTampaUSA

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