The Differentiated Contractile Effects of Prostaglandins on the Various Segments of the Pregnant Human Uterus
It is by now well established that prostanoids play a central role in the regulation of myometrial activity and thereby in the physiological control of human parturition (Liggins, 1979). Evidence for this concept is that exogenous PGs are effective for induction of labor (Karim et al., 1969; Thiery and Amy, 1975) and that inhibitors of PG biosynthesis are able both to delay spontaneous labor (Lewis and Schulman, 1973) and to inhibit preterm labor (Zuckerman et al., 1974; Wiqvist, 1979). To date, though, no evidence has emerged showing an increased formation of PG compounds prior to the spontaneous onset of parturition.
KeywordsLower Segment Lower Uterine Segment Spontaneous Labor Human Parturition Human Myometrium
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