Advertisement

Decreased Concentrations of Prostaglandin F in Delayed Labor

A Model for Studies on the Control of Prostaglandin Production by the Uterus
  • K. Reddi
  • A. Kambaran
  • S. M. Joubert
  • R. H. Philpott
  • R. J. Norman
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

The mechanisms responsible for the onset of spontaneous human labor at term are poorly understood. Furthermore, millions of neonates die every year as a result of the complications of pre- and postterm delivery. Although there are numerous theories, little progress has been made in determining the precise factors that permit the delivery of a mature and healthy baby.

Keywords

Amniotic Fluid Prostaglandin Production Free Arachidonic Acid Human Parturition Intrauterine Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bleasdale, J. E., Okazaki, T., Sagawa, N., DiRenzo, G., Okita, J. R., MacDonald, P. C, and Johnston, J. M., 1983, The mobilization of arachidonic acid for prostaglandin production during parturition, in: Initiation of Parturition: Prevention of Prematurity, Report of the Fourth Ross Conference on Obstetric Research (P. C. MacDonald and J. Porter, eds.), Ross Laboratories, Columbus, OH, pp. 129–136.Google Scholar
  2. Chard, T., Hudson, C.N., Edwards, C.R.W., and Boyd, N.R.H., 1971, Release of oxytocin and vasopressin by the human foetus during labour, Nature 254:352.CrossRefGoogle Scholar
  3. Cowan, D.B., van Middlekop, A., and Philpott, R.H., 1982, Intrauterine pressure studies in African nulliparae. Normal labour progress, Br. J. Obstet. Gynaecol. 81:257–263.Google Scholar
  4. Fuchs, F., 1983, Endocrinology of parturition, in: Endocrinology of Pregnancy (edF. Fuchs and A. Klopper, eds.), Harper & Row, Philadelphia, pp. 247–270.Google Scholar
  5. Karim, S.M.M., 1966, Identification of prostaglandins in amniotic fluid, Br. J. Obstet. Gynaecol. 73:903–908.CrossRefGoogle Scholar
  6. Karim, S.M.M., 1967, Prostaglandin content of amniotic fluid during pregnancy and labour, Br. J. Obstet. Gynaecol. 74:230–234.CrossRefGoogle Scholar
  7. Keirse, M.N.J.C, 1978, Biosynthesis and metabolism of prostaglandins in the pregnant human uterus, Adv. Prostaglandin Thromboxane Res. 4:87–102.PubMedGoogle Scholar
  8. Keirse, M. N. J. C, 1983, Prostaglandins during human parturition, in: Initiation of Parturition: Prevention of Prematurity, Report of the Fourth Ross Conference on Obstetric Research (P. C. MacDonald and J. Porter, eds.), Ross Laboratories, Columbus, OH, pp. 137–144.Google Scholar
  9. Keirse, M.N.J.C, and Turnbull, A.C., 1973, E prostaglandins in amniotic fluid during late pregnancy and labor, Br. J. Obstet. Gynecol. 80:970–973.CrossRefGoogle Scholar
  10. Keirse, M.N.J.C, Hint, A.P.F, and Turnbull, A.C, 1974, F prostaglandins in amniotic fluid during pregnancy and labor, Br. J. Obstet. Gynecol. 81:131–135.CrossRefGoogle Scholar
  11. Keirse, M.N.J.C, Hicks, B.R., Mitchell, M.D., and Turnbull, A.C, 1977, Increase of the prostaglandin precursor, arachidonic acid, in amniotic fluid during spontaneous labour, Br. J. Obstet. Gynaecol. 84:937–939.PubMedCrossRefGoogle Scholar
  12. Liggins, G.C, Fairclough, R.J., Grieves, S.A., Kendall, J.Z., and Knox, B.S., 1973, The mechanism of initiation of parturition in the ewe, Recent Prog. Horm. Res. 219:111–149.Google Scholar
  13. Mitchell, M.D., 1981, Prostaglandins during pregnancy and the perinatal period, J. Reprod. Fertil. 62:305–315.PubMedCrossRefGoogle Scholar
  14. Mitchell, M.D., Keirse, M.N.J.C, Anderson, A.B.M., and Turnbull, A.C, 1977, Evidence for a local control of prostaglandins within the pregnant human uterus, Br. J. Obstet. Gynaecol. 84:35–38.PubMedCrossRefGoogle Scholar
  15. Mitchell, M.D., Bibby, J., Hicks, B.R., and Turnbull, A.C, 1978, Specific production of prostaglandin E by human amnion in vitro, Prostaglandins 15:377–382.PubMedCrossRefGoogle Scholar
  16. Norman, R.J., and Joubert, S.M., 1982, Fetal urinary prostaglandins, Prostaglandins Leukotrienes Med. 8:171–172.CrossRefGoogle Scholar
  17. Norman, R.J., Bredenkamp, B.L.F., Joubert, S.M., and Beetar, C, 1981, Fetal prostaglandin levels in twin pregnancies, Prostaglandins Med. 6:309–316.PubMedCrossRefGoogle Scholar
  18. Norman, R.J., Deppe, W.M., Coutts, P.C, and Joubert, S.M., 1983, Twin pregnancy as a model for studies in fetal cortisol concentrations in labour: Relation to prostaglandins, prolactin and ACTH, Br. J. Obstet. Gynaecol. 90:1033–1039.PubMedCrossRefGoogle Scholar
  19. Nugteren, D.H., and Hazelhof, E., 1973, Isolation and properties of intermediates in prostaglandin biosynethsis, Biochim. Biophys. Acta, 326:448.PubMedCrossRefGoogle Scholar
  20. Okazaki, T., Okita, J.R., MacDonald, P.C, and Johnston, J.M., 1978, Initiation of human parturition: X. Substrate specificity of phospholipase A2 in human fetal membranes, Am. J. Obstet. Gynecol. 130:432–438.PubMedGoogle Scholar
  21. Philpott, R.H., 1972, Graphic records in labor, Br. Med. J. 4:163–165.PubMedCrossRefGoogle Scholar
  22. Reddi, K., Kambaran, S.R., Norman, R.J., Joubert, S.M., and Philpott, R.H., 1972, Abnormal concentrations of prostaglandins in amniotic fluid during delayed labour in multigravid patients, Br. J. Obstet. Gynaecol. 91:781–787.Google Scholar
  23. Robinson, J. S., and Mitchell, M. D., 1983, Prostaglandins and parturition, in: Initiation of Parturition: Prevention of Prematurity, Report of the Fourth Ross Conference on Obstetric Research (P. C. MacDonald and J. Porter, eds.), Ross Laboratories, Columbus, OH, pp. 71–77.Google Scholar
  24. Turnbull, A.C, Anderson, A.B.M., Flint, A.P.F., Jeremy, J.Y., Keirse, M.N.J.C, and Keirse, M.D., 1977, Human parturition, Ciba Found. Symp. 47:427–451.PubMedGoogle Scholar
  25. Zuckerman, H., Reiss, U., and Rubenstein, I., 1974, Inhibition of human premature labor by indo-methacin, Obstet. Gynecol. 44:787–792.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • K. Reddi
    • 1
  • A. Kambaran
    • 1
  • S. M. Joubert
    • 1
  • R. H. Philpott
    • 1
  • R. J. Norman
    • 1
  1. 1.Medical Research Council Unit for Preclinical Diagnostic ResearchUniversity of NatalCongellaSouth Africa

Personalised recommendations