Arachidonate Lipoxygenase Products and Psoriasis
Psoriasis is a common skin disease that, in many cases, appears to be genetically determined. Lesional skin is characterized by epidermal proliferation and inflammatory changes, of which intraepidermal neutrophil infiltration is a consistent finding and one of the earliest abnormalities seen in developing lesions (Chowaniec et al., 1981). Psoriasis may manifest clinically in various forms, of which the chronic, stable, scaly plaque type is the most common. However, the inflammatory changes predominate in some patients, and in generalized pustular psoriasis, an uncommon form of the disease, intraepidermal neutrophil microabscesses are the major pathological feature (Baker and Wilkinson, 1979). These findings suggest that the production of neutrophil chemoattractants by the epidermis may be important in the pathogenesis of psoriasis.
KeywordsArachidonic Acid Psoriatic Skin Psoriatic Lesion Lipoxygenase Product Chamber Fluid
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