A Two-Receptor Model for the Mechanism of Action of Prostaglandins in the Renal Collecting Tubule
Studies on the mechanism of action of steroid hormones have led to the concept that different steroids act through different receptors present in different target cells to elicit a common biochemical response, namely, regulation of transcription. One might presume that different prostaglandins also operate through different receptors to cause some common response. However, this response is still not defined. In this chapter we summarize our recent studies on the metabolism and function of prostaglandins by the renal collecting tubule (Garcia-Perez and Smith, 1983, 1984). Our major focus is to describe the development of a two-receptor model for the actions of prostaglandins in these cells.
KeywordsAdenylate Cyclase Tubule Cell Basolateral Side Basolateral Surface Thin Limb
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