Abstract
Studies on the mechanism of action of steroid hormones have led to the concept that different steroids act through different receptors present in different target cells to elicit a common biochemical response, namely, regulation of transcription. One might presume that different prostaglandins also operate through different receptors to cause some common response. However, this response is still not defined. In this chapter we summarize our recent studies on the metabolism and function of prostaglandins by the renal collecting tubule (Garcia-Perez and Smith, 1983, 1984). Our major focus is to describe the development of a two-receptor model for the actions of prostaglandins in these cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, R.J., Berl, T., McDonald, K.M., and Schrier, R.W., 1975, Evidence for an in vivo antagonism between vasopressin and prostaglandin in the mammalian kidney, J. Clin. Invest. 56:420–426.
Currie, M.G., and Needleman, P., 1982, Distribution of prostaglandin synthesis along the rabbit nephron, Fed. Proc. 41:1545.
Fejes-Toth, G. A., Magyar, A., and Walter, J., 1977, Renal response to vasopressin after inhibition of prostaglandin synthesis, Am. J. Physiol. 232:F416–F423.
Garcia-Perez, A., and Smith, W. L., 1983, Use of monoclonal antibodies to isolate cortical collecting tubule cells: AVP induces PGE release, Am. J. Physiol. 244:C211–C220.
Garcia-Perez, A., and Smith, W.L., 1984, Apical-basolateral membrane asymmetry in canine cortical collecting tubule cells: Bradykinin, arginine vasopressin, prostaglandin E2 interrelationships, J. Clin. Invest. 74:63–74.
Garrity, M.J., Andreason, T.J., Storm, D.R., and Robertson, R.P., 1983, Prostaglandin E-induced heterologous desensitization of hepatic adenylate cyclase: Consequences on the guanyl nucleotide regulatory complex, J. Biol. Chem. 258:8692–8697.
Grantham, J.J., and Orloff, J., 1968, Effect of prostaglandin E1 on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3′,5′-monophosphate and theophylline, J. Clin. Invest. 47:1154–1161.
Handler, J.S., and Orloff, J., 1981, Antidiuretic hormone, Annu. Rev. Physiol. 43:611–624.
Hansen, H.S., 1981, Essential fatty acid-supplemented diet increases renal excretion of prostaglandin E2 and water in essential fatty acid-deficient rats, Lipids 16:849–854.
Hassid, A., 1982, Regulation of prostaglandin biosynthesis in cultured cells, Am. J. Physiol. 243:C205–C211.
Hopkins, N.K., and Gorman, R.R., 1981, Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin, J. Clin. Invest. 67:540–546.
Kassis, S., and Fishman, P.H., 1982, Different mechanisms of desensitization of adenylate cyclase by isoproterenol and prostaglandin E1 in human fibroblasts, J. Biol. Chem. 257:5312–5381.
Lum, G.M., Aisenberg, G.A., Dunn, M.J., Berl, T., Schrier, R.W., and McDonald, K.M., 1977, In vivo effect of indomethacin to potentiate the renal medullary cyclic AMP response to vasopressin, J. Clin. Invest. 59:8–13.
Minkes, M., Stanford, N., Chi. M.-Y., Roth, G.J., Raz, A., Needleman, P., and Majerus, P.W., 1977, Cyclic adenosine 3′,5′-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions, J. Clin. Invest. 59:449–454.
Smith, W. L., and Bell, T. G., 1978, Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex, Am. J. Physiol. 235:F451–F457.
Smith, W.L., Bell, T.G., and Needleman, P., 1979, Increased renal tubular synthesis of prostaglandins in the rabbit kidney in response to ureteral obstruction, Prostaglandins 18:269–277.
Smith, W. L., Grenier, F. C, DeWitt, D. L., Garcia-Perez, A., and Bell, T. G., 1983, Cellular compartmentalization of the biosynthesis and function of PGE2 and PGI2 in the renal medulla, in: Prostaglandins and the Kidney (M. J. Dunn, C. Patrons, and G. A. Cinotti, eds.), Plenum Press, New York, pp. 27–39.
Torikai, S., and Kurokawa, K., 1981, Distribution of prostaglandin E2-sensitive adenylate cyclase along the rat nephron, Prostaglandins 21:427–438.
Torikai, S., and Kurokawa, K., 1983, Effect of PGE2 on vasopressin-dependent cell cAMP in isolated single nephron segments, Am. J. Physiol. 245: F58–F66.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer Science+Business Media New York
About this chapter
Cite this chapter
Smith, W.L., Garcia-Perez, A. (1985). A Two-Receptor Model for the Mechanism of Action of Prostaglandins in the Renal Collecting Tubule. In: Bailey, J.M. (eds) Prostaglandins, Leukotrienes, and Lipoxins. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4946-4_4
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4946-4_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4948-8
Online ISBN: 978-1-4684-4946-4
eBook Packages: Springer Book Archive