Comparative Absorption and Lymphatic Transport of (ω-3) Eicosapentaenoic Acid, (ω-6) Arachidonic Acid, and (ω-9) Oleic Acid

  • George V. Vahouny
  • Isabel S. Chen
  • S. Satchithanandam
  • Marie M. Cassidy
  • Alan J. Sheppard
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


There is a rapidly expanding literature on the dietary and metabolic effects of the ω-3 class of fatty acids, which include, among others, linolenic, eicosapentaenoic, and docosahexaenoic acids (Goodnight et al, 1982; Holman, 1982; Willis, 1981). Interest in this area has been heightened by the finding that population groups consuming greater quantities of fish and other marine animals, which are richer in (ω-3 fatty acids, have a low incidence of ischemie heart disease. These include Greenland Eskimos (Bang and Dyerberg, 1980), coastal-dwelling Turks (Yotakis, 1981), and Japanese residing in fishing villages (Hirai et al., 1980). In general, these populations have lower levels of fasting very-low-density and low-density lipoprotein cholesterol, increased levels of high-density lipoprotein cholesterol (Bang and Dyerberg, 1972), and a prolonged bleeding time (Dyerberg and Bang, 1979; Goodnight et al., 1981). These effects are largely attributed to the intake of marine fats, which contain, in addition to “common” fatty acids, higher levels of ω-3 fatty acids than are found in Western-type diets (Bang et al., 1976).


Oleic Acid Arachidonic Acid Eicosapentaenoic Acid Polyunsaturated Acid Lymphatic Transport 
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  1. Bang, H.O., and Dyerberg, J., 1972, Plasma lipids and lipoproteins in Greenland Eskimos, Ada Med. Scand. 192:85–94.CrossRefGoogle Scholar
  2. Bang, H. O., and Dyerberg, J., 1980, Lipid metabolism and ischémie heart disease, in: Advanced Nutrition Research, Vol. 3 (H. H. Draper, ed.), Plenum Press, New York, pp. 1–22.Google Scholar
  3. Bang, H.O., Dyerberg, J., and Hjorne, N., 1976, The composition of food consumed by Greenland Eskimos, Acta Med. Scand. 100:69–73.Google Scholar
  4. Bottino, N.R., Vandenberg, G.A., and Reiser, R., 1967, Resistance of certain long-chain polyun-saturated fatty acids of marine oils to pancreatic lipase hydrolysis, Lipids 2:489–493.PubMedCrossRefGoogle Scholar
  5. Brockerhoff, H., 1965, Stereospecific analysis of triglycerides: An analysis of human depot fat, Arch. Biochem. Biophys. 110:586–592.PubMedCrossRefGoogle Scholar
  6. Brockerhoff, H., Hoyle, R.J., and Huang, P.C, 1966, Positional distribution of fatty acids of a polar bear and a seal, Can. J. Biochem. 44:1519–1525.CrossRefGoogle Scholar
  7. Culp, B.R., Titus, B.G., and Lands, W.E.M., 1979, Inhibition of prostaglandin synthesis by eicosapentaenoic acid, Prostaglandins Med. 3:369–378.CrossRefGoogle Scholar
  8. Dyerberg, J., and Bang, H.O., 1979, Atherogenesis and haemostasis in Eskimos—the role of pros-taglandin-3 family, Haemostasis 8:227–233.PubMedGoogle Scholar
  9. Dyerberg, J., Jorgensen, J.A., and Arnfred, T., 1981, Human umbilical cord converts all cis 5,8,11,14,17-eicosapentaenoic acid to prostaglandin I3, Prostaglandins 22:857–862.PubMedCrossRefGoogle Scholar
  10. Folch, J., Lees, M., and Sloane-Stanley, G.H., 1957, Simple method for the isolation and purification of total lipids from animal tissues, J. Biol. Chem. 226:497–509.PubMedGoogle Scholar
  11. Gartner, S., and Vahouny, G.V., 1972, Effects of epinephrine and cAMP on perfused rat hearts, Am. J. Physiol. 222:1121–1124.PubMedGoogle Scholar
  12. Garton, G.A., Hilyditch, T.P., and Meara, M.L., 1952, The composition of depot fat of a pig fed on a diet rich in whale oil, Biochem. J. 50:517–524.PubMedGoogle Scholar
  13. Goodnight, S.H., Jr., Harris, W.S., and Connor, W.E., 1981, The effect of dietary ω-3 fatty acids on platelet composition and function in man: A prospective, controlled study, Blood 58:880–884.PubMedGoogle Scholar
  14. Goodnight, S.H., Jr., Harris, W.S., Connor, W.E., and Illingworth, D.E., 1982, Polyunsaturated fatty acids, hyperlipidemia and thrombosis, Arteriosclerosis 2:87–113.PubMedCrossRefGoogle Scholar
  15. Havel, R.J., Eder, H.A., and Bragdon, J.H., 1955, The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum, J. Clin. Invest. 34:1345–1353.PubMedCrossRefGoogle Scholar
  16. Harris, W. S., Connor, W. E., and Goodnight, S. H., Jr., 1982, Dietary fish oils, plasma lipids and platelets in man, in: Essential Fatty Acids and Prostaglandins (R. T. Holman, ed.), Pergamon Press, Oxford, pp. 75–79.Google Scholar
  17. Hay, C.R.M., Durber, A.P., and Saynor, R., 1982, Effect of fish oil on platelet kinetics in patients with ischaemic heart disease, Lancet 2:1269–1272.CrossRefGoogle Scholar
  18. Hirai, A., Hamazaki, T., Terano, T., Nishikawa, T., Tamura, Y., Kumagai, A., and Sajiki, J., 1980, Eicosapentaenoic acid and platelet function in Japanese, Lancet 2:1132–1133.PubMedCrossRefGoogle Scholar
  19. Holman, R. T. (ed.), 1982, Essential Fatty Acids and Prostaglandins. Progress in Lipid Research, Pergamon Press, Oxford.Google Scholar
  20. Jakobowski, J.A., and Ardlie, N.G., 1980, Cyclic AMP-independent inhibition of human platelet function by eicosapentaenoic acid, Thromb. Res. 17:751–752.3CrossRefGoogle Scholar
  21. Needleman, P., and Sprecher, H., 1979, Mechanism underlying the inhibition of platelet aggregation by eicosapentaenoic acid and its metabolites, Adv. Prostaglandin Thromboxane Res. 6:61–68.Google Scholar
  22. Needleman, P., Raz, A., Minkes, M. S., Ferrendelli, J. A., and Sprecher, H., 1979, Triene prostaglandins: Prostacyclin and thromboxane biosynthesis and unique biological properties, Proc. Natl. Acad. Sci. U.S.A. 76:944–948.PubMedCrossRefGoogle Scholar
  23. Needleman, P., Whitaker, M.C, and Sprecher, H., 1980, Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors—pharmacological basis for a therapeutic approach, Prostaglandins 19:165–181.PubMedCrossRefGoogle Scholar
  24. Spector, A.A., Kaduce, T.L., Figard, P.H., Norton, K.C, Hoak, J.C, and Czervionke, R.L., 1983, Eicosapentaenoic acid and prostacycl in production by cultured human endothelial cells, J. Lipid Res. 24:1595–1604.PubMedGoogle Scholar
  25. Treadwell, C. R., and Vahouny, G. V., 1968, Cholesterol absorption, in: Handbook of Physiology—Alimentary Canal, Sec. 6, Vol. II, American Physiological Society, Washington, D.C., pp. 1407–1438.Google Scholar
  26. Vahouny, G.V., Blendermann, E.M., Gallo, L.L., and Treadwell, C.R., 1980a, Differential transport cholesterol and oleic acid in lymph, J. Lipid Res. 21:415–424.PubMedGoogle Scholar
  27. Vahouny, G.V., Roy, T., Gallo, L.L., Story, J.A., Kritchevsky, D., and Cassidy, M.M., 1980b, Dietary Fiber. III. Effects of chronic intake on cholesterol absorption and metabolism in the rat, Am. J. Clin. Nutr. 33:2182–2191.PubMedGoogle Scholar
  28. Vahouny, G.V., Satchithanandam, S., Cassidy, M.M., Lightfoot, F.G., and Furda, I., 1983, Comparative effects of chitosan and cholestyramine on lymphatic absorption of lipids in the rat, Am. J. Clin. Nutr. 38:278–284.PubMedGoogle Scholar
  29. Witaker, M.O., Wyche, A., Fitzpatrick, F., Sprecher, H., and Needleman, P., 1979, Triene prostaglandins: Prostaglandin D3 and eicosapentaenoic acid as potential antithrombotic substances, Proc. Natl. Acad. Sci. U.S.A. 76:5919–5923.CrossRefGoogle Scholar
  30. Willis, A.L., 1981, Nutritional and pharmacological factors in eicosanoid-biology, Nutr. Rev. 39:289–301.PubMedCrossRefGoogle Scholar
  31. Yotakis, L.D.O., 1981, The preventive effects of polyunsaturated fats on thrombosis, Thromb. Haemostas. 46:65–68.Google Scholar
  32. Yurkowski, M., and Brockerhoff, H., 1966, Fatty acid distribution of triglycerides determined by deacylation with methyl magnesium bromide, Biochim. Biophys. Acta 125:55–59.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • George V. Vahouny
    • 1
  • Isabel S. Chen
    • 1
  • S. Satchithanandam
    • 1
  • Marie M. Cassidy
    • 2
  • Alan J. Sheppard
    • 3
  1. 1.Department of BiochemistryThe George Washington University School of Medicine and Health SciencesUSA
  2. 2.Department of PhysiologyThe George Washington University School of Medicine and Health SciencesUSA
  3. 3.Division of NutritionFood and Drug AdministrationUSA

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