Effects of Selenium Deficiency on Arachidonic Acid Metabolism and Aggregation in Rat Platelets
Evidence from investigations in the early 1970s indicated the possibility of an interaction between the metabolism of arachidonic acid and the activity of selenium (Se)-dependent glutathione peroxidase(GSHPx, E.C. 126.96.36.199). Lands et al. (1971) reported that the addition of GSHPx to preparations of prostaglandin (PG) synthase and soybean lipoxygenase inhibited the activity of these two dioxygenases. These initial experiments were followed by a series of studies (see review, Warso and Lands, 1983) that demonstrated the peroxide requirement for activation and maintenance of the catalytic activity of PG synthase in vitro. In 1973, it was discovered that GSHPx contained selenium as a necessary component for activity (Rotruck et al., 1973). It is this requirement that has been exploited by investigators to study the relationship between GSHPx and arachidonic acid metabolism, since GSHPx activity can be manipulated by dietary selenium (see reviews, Sunde and Hoekstra, 1980; Schoene, 1985).
KeywordsArachidonic Acid GSHPx Activity Arachidonic Acid Metabolism Selenium Deficiency Arachidonic Acid Metabolite
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